Cerebrovascular Complications in Bacterial Meningitis
The objective is to describe a comprehensive analysis of patients with bacterial meningitis exacerbate by cerebrovascular complications. We reviewed the literature on cerebrovascular complications in adult patients with bacterial meningitis. Cerebrovascular complications occur in one fourth of patie...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Stroke: Vascular and Interventional Neurology |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.123.001435 |
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| author | Shahrzad S. Deliran Matthijs C. Brouwer Diederik van de Beek |
| author_facet | Shahrzad S. Deliran Matthijs C. Brouwer Diederik van de Beek |
| author_sort | Shahrzad S. Deliran |
| collection | DOAJ |
| description | The objective is to describe a comprehensive analysis of patients with bacterial meningitis exacerbate by cerebrovascular complications. We reviewed the literature on cerebrovascular complications in adult patients with bacterial meningitis. Cerebrovascular complications occur in one fourth of patients with bacterial meningitis. The most common cerebrovascular disease complicating bacterial meningitis are cerebral infarctions (9%–25%), intracerebral hemorrhage (1%–7%), cerebral venous thrombosis (1%–10%), and subarachnoid hemorrhage (1%–5%). Streptococcus pneumoniae and Staphylococcus aureus are the primary causative pathogens leading to these complications. The pathophysiological mechanisms have not completely been elucidated but involve vasculitis, endothelial dysfunction, hypercoagulability, aggregation, and complement activation. Cerebrovascular complications are important predictors of unfavorable outcome and death, and the use of adjunctive dexamethasone has been described to reduce the incidence. In conclusion, cerebrovascular complications are common in bacterial meningitis and are strongly associated with unfavorable outcomes and death. Although our understanding of the pathophysiology is evolving, there remains a need for novel treatment strategies to address these complications. |
| format | Article |
| id | doaj-art-688e6dd89f754d699850b5c571f96d6c |
| institution | Kabale University |
| issn | 2694-5746 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj-art-688e6dd89f754d699850b5c571f96d6c2025-01-11T08:01:41ZengWileyStroke: Vascular and Interventional Neurology2694-57462025-01-015110.1161/SVIN.123.001435Cerebrovascular Complications in Bacterial MeningitisShahrzad S. Deliran0Matthijs C. Brouwer1Diederik van de Beek2Department of Neurology, Amsterdam Neuroscience Amsterdam UMC, University of Amsterdam Amsterdam The NetherlandsDepartment of Neurology, Amsterdam Neuroscience Amsterdam UMC, University of Amsterdam Amsterdam The NetherlandsDepartment of Neurology, Amsterdam Neuroscience Amsterdam UMC, University of Amsterdam Amsterdam The NetherlandsThe objective is to describe a comprehensive analysis of patients with bacterial meningitis exacerbate by cerebrovascular complications. We reviewed the literature on cerebrovascular complications in adult patients with bacterial meningitis. Cerebrovascular complications occur in one fourth of patients with bacterial meningitis. The most common cerebrovascular disease complicating bacterial meningitis are cerebral infarctions (9%–25%), intracerebral hemorrhage (1%–7%), cerebral venous thrombosis (1%–10%), and subarachnoid hemorrhage (1%–5%). Streptococcus pneumoniae and Staphylococcus aureus are the primary causative pathogens leading to these complications. The pathophysiological mechanisms have not completely been elucidated but involve vasculitis, endothelial dysfunction, hypercoagulability, aggregation, and complement activation. Cerebrovascular complications are important predictors of unfavorable outcome and death, and the use of adjunctive dexamethasone has been described to reduce the incidence. In conclusion, cerebrovascular complications are common in bacterial meningitis and are strongly associated with unfavorable outcomes and death. Although our understanding of the pathophysiology is evolving, there remains a need for novel treatment strategies to address these complications.https://www.ahajournals.org/doi/10.1161/SVIN.123.001435bacterial meningitiscerebral venous thrombosiscerebrovascular complicationdelayed cerebral thrombosisintracerebral hemorrhagestreptococcus pneumonia |
| spellingShingle | Shahrzad S. Deliran Matthijs C. Brouwer Diederik van de Beek Cerebrovascular Complications in Bacterial Meningitis Stroke: Vascular and Interventional Neurology bacterial meningitis cerebral venous thrombosis cerebrovascular complication delayed cerebral thrombosis intracerebral hemorrhage streptococcus pneumonia |
| title | Cerebrovascular Complications in Bacterial Meningitis |
| title_full | Cerebrovascular Complications in Bacterial Meningitis |
| title_fullStr | Cerebrovascular Complications in Bacterial Meningitis |
| title_full_unstemmed | Cerebrovascular Complications in Bacterial Meningitis |
| title_short | Cerebrovascular Complications in Bacterial Meningitis |
| title_sort | cerebrovascular complications in bacterial meningitis |
| topic | bacterial meningitis cerebral venous thrombosis cerebrovascular complication delayed cerebral thrombosis intracerebral hemorrhage streptococcus pneumonia |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.123.001435 |
| work_keys_str_mv | AT shahrzadsdeliran cerebrovascularcomplicationsinbacterialmeningitis AT matthijscbrouwer cerebrovascularcomplicationsinbacterialmeningitis AT diederikvandebeek cerebrovascularcomplicationsinbacterialmeningitis |