SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT
ABSTRACT Background: Purpura fulminans (PF) is a rapidly progressive thrombotic disorder affecting neonates and children and adults in which there is haemorrhagic infarction of skin and disseminated intravascular coagulation. Gram-negative organisms especially due to Neisseria meningitides are ce...
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1900 |
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| author | Joaquin Valle Alonso |
| author_facet | Joaquin Valle Alonso |
| author_sort | Joaquin Valle Alonso |
| collection | DOAJ |
| description | ABSTRACT
Background: Purpura fulminans (PF) is a rapidly progressive thrombotic disorder affecting neonates and children and adults in which there is haemorrhagic infarction of skin and disseminated intravascular coagulation. Gram-negative organisms especially due to Neisseria meningitides are certainly the commonest hematogenous infection known to induce PF and the commonest cause of the acute infection type. Objectives: We report a case of a survival case of a patient with purpura fulminas associated with meningococcal septicemia in an adult with transient protein deficit C deficit. In addition we review the etiology, clinical features and current treatment. Case Report: A 19-year-old woman was admitted to the emergency department because of oliguria, fever, and a diffuse rash. Her skin examination showed a diffuse, palpable purpuric rash consistent with purpura fulminans. Hypoxic respiratory failure with the development of acute respiratory distress syndrome and anuric renal failure quickly developed. Laboratory tests revealed disseminated intravascular coagulation she also had clinical findings of the Waterhouse–Friderichsen syndrome. The clinical course was complicated with acute tubular necrosis and Klebsiella pneumonia. The bronchoalveolar lavage gram stain and culture grew Gram-negative diplococci. Transient deficiency of protein S was observed and normalized after 10 days. After treatment in the Intensive Care Unit the patient’s evolution was favorable and she was discharged from hospital at 32 days after admission. Conclusions Purpura fulminans associated with meningococcemia is a devastating but rare disease with high mortality. Early diagnosis and proper treatment is necessary to prevent death from this otherwise fatal condition |
| format | Article |
| id | doaj-art-6887b1afc7c24be2af5b3bc1640d9bfb |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-6887b1afc7c24be2af5b3bc1640d9bfb2025-01-02T01:36:03ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORTJoaquin Valle Alonso0Correspondence: Dr. Joaquín Valle Alonso MD Departament of Emergency and Critical care Medicine, Hospital Valle de los Pedroches Pozoblanco, Córdoba, Spain., E-mail: joa51274@hotmail.comABSTRACT Background: Purpura fulminans (PF) is a rapidly progressive thrombotic disorder affecting neonates and children and adults in which there is haemorrhagic infarction of skin and disseminated intravascular coagulation. Gram-negative organisms especially due to Neisseria meningitides are certainly the commonest hematogenous infection known to induce PF and the commonest cause of the acute infection type. Objectives: We report a case of a survival case of a patient with purpura fulminas associated with meningococcal septicemia in an adult with transient protein deficit C deficit. In addition we review the etiology, clinical features and current treatment. Case Report: A 19-year-old woman was admitted to the emergency department because of oliguria, fever, and a diffuse rash. Her skin examination showed a diffuse, palpable purpuric rash consistent with purpura fulminans. Hypoxic respiratory failure with the development of acute respiratory distress syndrome and anuric renal failure quickly developed. Laboratory tests revealed disseminated intravascular coagulation she also had clinical findings of the Waterhouse–Friderichsen syndrome. The clinical course was complicated with acute tubular necrosis and Klebsiella pneumonia. The bronchoalveolar lavage gram stain and culture grew Gram-negative diplococci. Transient deficiency of protein S was observed and normalized after 10 days. After treatment in the Intensive Care Unit the patient’s evolution was favorable and she was discharged from hospital at 32 days after admission. Conclusions Purpura fulminans associated with meningococcemia is a devastating but rare disease with high mortality. Early diagnosis and proper treatment is necessary to prevent death from this otherwise fatal conditionhttps://mjhid.org/index.php/mjhid/article/view/1900MENINGOCOCCALSEPTICEMIAPURPURA FULMINASPROTEIN C DEFICIENCYWATERHOUSE-FRIERICHSEN SYNDROME. |
| spellingShingle | Joaquin Valle Alonso SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT Mediterranean Journal of Hematology and Infectious Diseases MENINGOCOCCAL SEPTICEMIA PURPURA FULMINAS PROTEIN C DEFICIENCY WATERHOUSE-FRIERICHSEN SYNDROME. |
| title | SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT |
| title_full | SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT |
| title_fullStr | SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT |
| title_full_unstemmed | SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT |
| title_short | SURVIVAL CASE OF PURPURA FULMINANS IN MENINGOCOCCAL SEPTICAEMIA IN AN ADULT WITH TRANSIENT PROTEIN C DEFICIENCY: A CASE REPORT |
| title_sort | survival case of purpura fulminans in meningococcal septicaemia in an adult with transient protein c deficiency a case report |
| topic | MENINGOCOCCAL SEPTICEMIA PURPURA FULMINAS PROTEIN C DEFICIENCY WATERHOUSE-FRIERICHSEN SYNDROME. |
| url | https://mjhid.org/index.php/mjhid/article/view/1900 |
| work_keys_str_mv | AT joaquinvallealonso survivalcaseofpurpurafulminansinmeningococcalsepticaemiainanadultwithtransientproteincdeficiencyacasereport |