The role of gene copy number variation in antimicrobial resistance in human fungal pathogens
Abstract Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. Fungi have relatively plastic genomes and can tolerate genomic copy num...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-024-00072-1 |
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| author | Adarsh Jay David F. Jordan Aleeza Gerstein Christian R. Landry |
| author_facet | Adarsh Jay David F. Jordan Aleeza Gerstein Christian R. Landry |
| author_sort | Adarsh Jay |
| collection | DOAJ |
| description | Abstract Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. Fungi have relatively plastic genomes and can tolerate genomic copy number variation (CNV) caused by aneuploidy and gene amplification or deletion. In many cases, these genomic changes lead to adaptation to stressful conditions, including those caused by antifungal drugs. Here, we specifically examine the contribution of CNVs to antifungal resistance. We undertook a thorough literature search, collecting reports of antifungal resistance caused by a CNV, and classifying the examples of CNV-conferred resistance into four main mechanisms. We find that in human fungal pathogens, there is little evidence that gene copy number plays a major role in the emergence of antifungal resistance compared to other types of mutations. We discuss why we might be underestimating their importance and new approaches being used to study them. |
| format | Article |
| id | doaj-art-6877e4f359814184969598d5ff602096 |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-6877e4f359814184969598d5ff6020962025-01-12T12:41:25ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-01-01311810.1038/s44259-024-00072-1The role of gene copy number variation in antimicrobial resistance in human fungal pathogensAdarsh Jay0David F. Jordan1Aleeza Gerstein2Christian R. Landry3Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université LavalDépartement de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université LavalDepartment of Microbiology, The University of ManitobaDépartement de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université LavalAbstract Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. Fungi have relatively plastic genomes and can tolerate genomic copy number variation (CNV) caused by aneuploidy and gene amplification or deletion. In many cases, these genomic changes lead to adaptation to stressful conditions, including those caused by antifungal drugs. Here, we specifically examine the contribution of CNVs to antifungal resistance. We undertook a thorough literature search, collecting reports of antifungal resistance caused by a CNV, and classifying the examples of CNV-conferred resistance into four main mechanisms. We find that in human fungal pathogens, there is little evidence that gene copy number plays a major role in the emergence of antifungal resistance compared to other types of mutations. We discuss why we might be underestimating their importance and new approaches being used to study them.https://doi.org/10.1038/s44259-024-00072-1 |
| spellingShingle | Adarsh Jay David F. Jordan Aleeza Gerstein Christian R. Landry The role of gene copy number variation in antimicrobial resistance in human fungal pathogens npj Antimicrobials and Resistance |
| title | The role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| title_full | The role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| title_fullStr | The role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| title_full_unstemmed | The role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| title_short | The role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| title_sort | role of gene copy number variation in antimicrobial resistance in human fungal pathogens |
| url | https://doi.org/10.1038/s44259-024-00072-1 |
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