High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients
Abstract The molecular profile of paracancerous tissue has been reported to be prognostic for recurrence in patients with different cancers. This study investigated the clinical significance of the protein expression of gamma-butyrobetaine hydroxylase 1 (BBOX1) in tumor and paracancerous tissues of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-78127-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846158596621991936 |
|---|---|
| author | Runqi Fang Yuling Zhan Xiang Dong Suwan Li Minghui Yang Yunxia Zhao Yu Gao |
| author_facet | Runqi Fang Yuling Zhan Xiang Dong Suwan Li Minghui Yang Yunxia Zhao Yu Gao |
| author_sort | Runqi Fang |
| collection | DOAJ |
| description | Abstract The molecular profile of paracancerous tissue has been reported to be prognostic for recurrence in patients with different cancers. This study investigated the clinical significance of the protein expression of gamma-butyrobetaine hydroxylase 1 (BBOX1) in tumor and paracancerous tissues of hepatocellular carcinoma (HCC) patients. This study assessed the role of BBOX1 mRNA in tumor and paracancerous tissues in HCC via bioinformatics analysis. The protein levels of BBOX1 in paired tumor and paracancerous tissues from 83 HCC patients were determined by immunohistochemistry. The associations among BBOX1 protein levels, clinicopathological characteristics and the survival probability of HCC patients were also analyzed. The results revealed that BBOX1 mRNA expression was significantly lower in HCC tissues than in noncancerous tissues. HCC patients with low BBOX1 mRNA expression had a significantly poorer overall survival than those with high BBOX1 expression did. Immunohistochemical analysis of BBOX1 protein expression further confirmed that its levels were markedly lower in HCC tissues than in paracancerous tissues. High BBOX1 expression in paracancerous tissues correlated with poor overall survival and disease-free survival in HCC patients. These findings suggest that the paracancerous BBOX1 expression might be a credible indicator for overall survival or disease-free survival in HCC patients. |
| format | Article |
| id | doaj-art-687366ce53aa47c4997d6123a6f37f2b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-687366ce53aa47c4997d6123a6f37f2b2024-11-24T12:22:29ZengNature PortfolioScientific Reports2045-23222024-11-011411810.1038/s41598-024-78127-6High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patientsRunqi Fang0Yuling Zhan1Xiang Dong2Suwan Li3Minghui Yang4Yunxia Zhao5Yu Gao6School of Clinical Medicine, Bengbu Medical UniversitySchool of Life Science, Bengbu Medical UniversitySchool of Life Science, Bengbu Medical UniversitySchool of Life Science, Bengbu Medical UniversitySchool of Life Science, Bengbu Medical UniversitySchool of Basic Medical, Bengbu Medical UniversitySchool of Life Science, Bengbu Medical UniversityAbstract The molecular profile of paracancerous tissue has been reported to be prognostic for recurrence in patients with different cancers. This study investigated the clinical significance of the protein expression of gamma-butyrobetaine hydroxylase 1 (BBOX1) in tumor and paracancerous tissues of hepatocellular carcinoma (HCC) patients. This study assessed the role of BBOX1 mRNA in tumor and paracancerous tissues in HCC via bioinformatics analysis. The protein levels of BBOX1 in paired tumor and paracancerous tissues from 83 HCC patients were determined by immunohistochemistry. The associations among BBOX1 protein levels, clinicopathological characteristics and the survival probability of HCC patients were also analyzed. The results revealed that BBOX1 mRNA expression was significantly lower in HCC tissues than in noncancerous tissues. HCC patients with low BBOX1 mRNA expression had a significantly poorer overall survival than those with high BBOX1 expression did. Immunohistochemical analysis of BBOX1 protein expression further confirmed that its levels were markedly lower in HCC tissues than in paracancerous tissues. High BBOX1 expression in paracancerous tissues correlated with poor overall survival and disease-free survival in HCC patients. These findings suggest that the paracancerous BBOX1 expression might be a credible indicator for overall survival or disease-free survival in HCC patients.https://doi.org/10.1038/s41598-024-78127-6Gamma-butyrobetaine hydroxylase 1 (BBOX1)Hepatocellular carcinoma (HCC)Paracancerous tissueOverall survivalDisease-free survival |
| spellingShingle | Runqi Fang Yuling Zhan Xiang Dong Suwan Li Minghui Yang Yunxia Zhao Yu Gao High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients Scientific Reports Gamma-butyrobetaine hydroxylase 1 (BBOX1) Hepatocellular carcinoma (HCC) Paracancerous tissue Overall survival Disease-free survival |
| title | High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| title_full | High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| title_fullStr | High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| title_full_unstemmed | High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| title_short | High expression of BBOX1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| title_sort | high expression of bbox1 in paracancerous tissue is associated with poor prognosis in hepatocellular carcinoma patients |
| topic | Gamma-butyrobetaine hydroxylase 1 (BBOX1) Hepatocellular carcinoma (HCC) Paracancerous tissue Overall survival Disease-free survival |
| url | https://doi.org/10.1038/s41598-024-78127-6 |
| work_keys_str_mv | AT runqifang highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT yulingzhan highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT xiangdong highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT suwanli highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT minghuiyang highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT yunxiazhao highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients AT yugao highexpressionofbbox1inparacanceroustissueisassociatedwithpoorprognosisinhepatocellularcarcinomapatients |