The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018
Abstract Evidence suggest that dietary advanced glycation end products (AGEs) might exert harmful effects on female reproductive function. However, population-based studies exploring the associations between dietary AGEs intake and female infertility remain lacking. This studyaimed to determine the...
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Nature Portfolio
2025-01-01
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| author | Lingxia Tong Xiaohui Zhang Jingsi Chen Huanying He Wenzhuo Zhang Zhongxiao Wan Hong Zhang |
| author_facet | Lingxia Tong Xiaohui Zhang Jingsi Chen Huanying He Wenzhuo Zhang Zhongxiao Wan Hong Zhang |
| author_sort | Lingxia Tong |
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| description | Abstract Evidence suggest that dietary advanced glycation end products (AGEs) might exert harmful effects on female reproductive function. However, population-based studies exploring the associations between dietary AGEs intake and female infertility remain lacking. This studyaimed to determine the relationship between dietary AGEs intake and female infertility based on National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis of 2863 participants in the NHANES 2013–2018 were included. The dietary AGEs, i.e. Nε-(carboxymethyl)lysine(CML), Nε-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated using the combination of ultra-performance LC-tandem MS dietary AGEs database and two 24-h dietary recall interviews. Multivariate Logistic regression analyses were adopted to explore the relationships between dietary AGEs intake and self-reported infertility risk. Compared to the lowest tertile, total dietary AGEs (P-trend = 0.089) and CML (P-trend = 0.032) in the upper tertile were positively correlated with female infertility, and the corresponding odds radios (ORs) (95% confidence interval (CI)) were 1.44 (1.01, 2.06) and 1.64 (1.10, 2.45) respectively. Subgroups analysis found that in participants with overweight and obese, each 1-SD increment in dietary AGEs, CML and MG-H1 level was associated with 18% (95% CI: 1-38%), 21% (95% CI: 1-46%), and 16% (95% CI: 0-36%) elevated risk of infertility. Elevated dietary AGEs intake was associated with the higher risk of infertility for female subjects, this positive association was more pronounced in women with excess body weight. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Scientific Reports |
| spelling | doaj-art-687112bbfb72435eafe1b120799087c22025-01-12T12:22:40ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-85361-zThe associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018Lingxia Tong0Xiaohui Zhang1Jingsi Chen2Huanying He3Wenzhuo Zhang4Zhongxiao Wan5Hong Zhang6Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow UniversityDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityAbstract Evidence suggest that dietary advanced glycation end products (AGEs) might exert harmful effects on female reproductive function. However, population-based studies exploring the associations between dietary AGEs intake and female infertility remain lacking. This studyaimed to determine the relationship between dietary AGEs intake and female infertility based on National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis of 2863 participants in the NHANES 2013–2018 were included. The dietary AGEs, i.e. Nε-(carboxymethyl)lysine(CML), Nε-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated using the combination of ultra-performance LC-tandem MS dietary AGEs database and two 24-h dietary recall interviews. Multivariate Logistic regression analyses were adopted to explore the relationships between dietary AGEs intake and self-reported infertility risk. Compared to the lowest tertile, total dietary AGEs (P-trend = 0.089) and CML (P-trend = 0.032) in the upper tertile were positively correlated with female infertility, and the corresponding odds radios (ORs) (95% confidence interval (CI)) were 1.44 (1.01, 2.06) and 1.64 (1.10, 2.45) respectively. Subgroups analysis found that in participants with overweight and obese, each 1-SD increment in dietary AGEs, CML and MG-H1 level was associated with 18% (95% CI: 1-38%), 21% (95% CI: 1-46%), and 16% (95% CI: 0-36%) elevated risk of infertility. Elevated dietary AGEs intake was associated with the higher risk of infertility for female subjects, this positive association was more pronounced in women with excess body weight.https://doi.org/10.1038/s41598-025-85361-zDietary advanced glycation end productsInfertilityMultivariate regression analysisNational Health and Nutrition Examination SurveyObesity |
| spellingShingle | Lingxia Tong Xiaohui Zhang Jingsi Chen Huanying He Wenzhuo Zhang Zhongxiao Wan Hong Zhang The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 Scientific Reports Dietary advanced glycation end products Infertility Multivariate regression analysis National Health and Nutrition Examination Survey Obesity |
| title | The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 |
| title_full | The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 |
| title_fullStr | The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 |
| title_full_unstemmed | The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 |
| title_short | The associations between dietary advanced glycation-end products intake and self-reported infertility in U.S. women: data from the NHANES 2013–2018 |
| title_sort | associations between dietary advanced glycation end products intake and self reported infertility in u s women data from the nhanes 2013 2018 |
| topic | Dietary advanced glycation end products Infertility Multivariate regression analysis National Health and Nutrition Examination Survey Obesity |
| url | https://doi.org/10.1038/s41598-025-85361-z |
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