The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018
ObjectivesDespite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between the Metabolic Score for Visceral Fat (METS-VF) and HUA remain insufficient. This research focused on METS-VF’s potential role as a risk factor for...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1497529/full |
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| author | Lin Xie Huali Qu Dandan Lai Juan Li Xushan Chen Jiajia Xie |
| author_facet | Lin Xie Huali Qu Dandan Lai Juan Li Xushan Chen Jiajia Xie |
| author_sort | Lin Xie |
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| description | ObjectivesDespite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between the Metabolic Score for Visceral Fat (METS-VF) and HUA remain insufficient. This research focused on METS-VF’s potential role as a risk factor for HUA.MethodsNotably, 8,659 participants from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup analysis, interaction test, and restricted cubic spline (RCS) analysis were implemented to identify the correlation between METS-VF and HUA.ResultsIn the fully adjusted model, the results of the multiple logistic regression analysis indicated that METS-VF was related to an elevated prevalence of HUA [before PSM: odds ratio (OR) = 3.51 (2.88, 4.27), p < 0.001; after PSM: OR = 2.90 (2.36, 3.58), p < 0.001]. In RCS analysis, a non-linear positive correlation was observed between METS-VF and the incidence of HUA (before PSM: p-non-linear <0.001; after PSM: p-non-linear = 0.0065). Subgroup analysis and interaction tests revealed that the impact of METS-VF on HUA was modified by sex and ethnicity.ConclusionThere is a significant positive correlation between METS-VF and HUA in adults in the United States. METS-VF could serve as a valuable metric for assessing the development and progression of HUA. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-686dfc70a22b4e07b7e5dacb81dec4c62025-01-10T14:29:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14975291497529The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018Lin Xie0Huali Qu1Dandan Lai2Juan Li3Xushan Chen4Jiajia Xie5The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaObjectivesDespite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between the Metabolic Score for Visceral Fat (METS-VF) and HUA remain insufficient. This research focused on METS-VF’s potential role as a risk factor for HUA.MethodsNotably, 8,659 participants from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup analysis, interaction test, and restricted cubic spline (RCS) analysis were implemented to identify the correlation between METS-VF and HUA.ResultsIn the fully adjusted model, the results of the multiple logistic regression analysis indicated that METS-VF was related to an elevated prevalence of HUA [before PSM: odds ratio (OR) = 3.51 (2.88, 4.27), p < 0.001; after PSM: OR = 2.90 (2.36, 3.58), p < 0.001]. In RCS analysis, a non-linear positive correlation was observed between METS-VF and the incidence of HUA (before PSM: p-non-linear <0.001; after PSM: p-non-linear = 0.0065). Subgroup analysis and interaction tests revealed that the impact of METS-VF on HUA was modified by sex and ethnicity.ConclusionThere is a significant positive correlation between METS-VF and HUA in adults in the United States. METS-VF could serve as a valuable metric for assessing the development and progression of HUA.https://www.frontiersin.org/articles/10.3389/fnut.2024.1497529/fullhyperuricemiavisceral fatcross-sectional surveypropensity score matchingNHANES |
| spellingShingle | Lin Xie Huali Qu Dandan Lai Juan Li Xushan Chen Jiajia Xie The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 Frontiers in Nutrition hyperuricemia visceral fat cross-sectional survey propensity score matching NHANES |
| title | The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 |
| title_full | The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 |
| title_fullStr | The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 |
| title_full_unstemmed | The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 |
| title_short | The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 |
| title_sort | association of visceral fat metabolism score with hyperuricemia evidence from nhanes 1999 2018 |
| topic | hyperuricemia visceral fat cross-sectional survey propensity score matching NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1497529/full |
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