Metal Complexes and Their Role in Treatment of the Arthritis
Worldwide, rheumatoid arthritis is a major cause of morbidity and mortality. In recent years, the domain of inorganic medicinal chemistry has shown more interest in metal-based drugs owing to their beneficial pharmacological activities. Since then, many useful anti-cancer metal-based drugs have been...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-10-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/metal-complexes-and-their-role-in-treatment-of-the-arthritis/doi/gmj.2024.3866 |
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| author | Ejaz Ali Kanwal Ashiq Manhaz Ghulam Nabi Maria Gul Mubashra Gul |
| author_facet | Ejaz Ali Kanwal Ashiq Manhaz Ghulam Nabi Maria Gul Mubashra Gul |
| author_sort | Ejaz Ali |
| collection | DOAJ |
| description | Worldwide, rheumatoid arthritis is a major cause of morbidity and mortality. In recent years, the domain of inorganic medicinal chemistry has shown more interest in metal-based drugs owing to their beneficial pharmacological activities. Since then, many useful anti-cancer metal-based drugs have been introduced. However, less attention has been paid to improving inflammatory drugs based on metal complexes. The objective of this review is to recapitulate previously published studies that concentrated on metal-based drugs used for the treatment of arthritis. It is anticipated that the current compilation of earlier studies will be helpful for the researcher to find the data and areas for future studies. The literature survey was done without any time limit using the help of various electronic databases, including ScienceDirect, SpringerLink, Web of Science, PubMed, and the Cochrane Library. Articles published in the English language are used for the current review. Only 20 studies were found to be pertinent to the present review. Metal complexes of non-steroidal anti-inflammatory drugs have been the subject of extensive research. To date, metal complexes of drugs such as aspirin, ibuprofen, anthranilic acid, methotrexate, indomethacin, and aceclofenac have been studied and evaluated for their possible antiarthritic activity. Gold metal complexes showed better efficacy and have been used in clinical practice as well. Due to their advantageous therapeutic properties, metals and their complexes are becoming more and more important today. To find new treatments for diseases, it is suggested that the mechanism of action and potential toxicity of metal complexes must be assessed. |
| format | Article |
| id | doaj-art-68470b03081a48d6a7b59934c6486c09 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-68470b03081a48d6a7b59934c6486c092025-01-16T11:33:48ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-10-0135445245610.12996/gmj.2024.3866Metal Complexes and Their Role in Treatment of the ArthritisEjaz Ali0https://orcid.org/0000-0001-7421-3701Kanwal Ashiq1https://orcid.org/0000-0001-8193-5147Manhaz Ghulam Nabi2Maria Gul3Mubashra Gul4University of the Punjab University College of Pharmacy, Lahore, PakistanUniversity of the Punjab University College of Pharmacy, Lahore, PakistanUniversity of the Punjab University College of Pharmacy, Lahore, PakistanRiphah International University Faculty of Pharmacy, Lahore, PakistanRiphah International University Faculty of Pharmacy, Lahore, PakistanWorldwide, rheumatoid arthritis is a major cause of morbidity and mortality. In recent years, the domain of inorganic medicinal chemistry has shown more interest in metal-based drugs owing to their beneficial pharmacological activities. Since then, many useful anti-cancer metal-based drugs have been introduced. However, less attention has been paid to improving inflammatory drugs based on metal complexes. The objective of this review is to recapitulate previously published studies that concentrated on metal-based drugs used for the treatment of arthritis. It is anticipated that the current compilation of earlier studies will be helpful for the researcher to find the data and areas for future studies. The literature survey was done without any time limit using the help of various electronic databases, including ScienceDirect, SpringerLink, Web of Science, PubMed, and the Cochrane Library. Articles published in the English language are used for the current review. Only 20 studies were found to be pertinent to the present review. Metal complexes of non-steroidal anti-inflammatory drugs have been the subject of extensive research. To date, metal complexes of drugs such as aspirin, ibuprofen, anthranilic acid, methotrexate, indomethacin, and aceclofenac have been studied and evaluated for their possible antiarthritic activity. Gold metal complexes showed better efficacy and have been used in clinical practice as well. Due to their advantageous therapeutic properties, metals and their complexes are becoming more and more important today. To find new treatments for diseases, it is suggested that the mechanism of action and potential toxicity of metal complexes must be assessed.https://gazimedj.com/articles/metal-complexes-and-their-role-in-treatment-of-the-arthritis/doi/gmj.2024.3866rheumatoid arthritismetal complexesinflammationnsaidsdmars |
| spellingShingle | Ejaz Ali Kanwal Ashiq Manhaz Ghulam Nabi Maria Gul Mubashra Gul Metal Complexes and Their Role in Treatment of the Arthritis Gazi Medical Journal rheumatoid arthritis metal complexes inflammation nsaids dmars |
| title | Metal Complexes and Their Role in Treatment of the Arthritis |
| title_full | Metal Complexes and Their Role in Treatment of the Arthritis |
| title_fullStr | Metal Complexes and Their Role in Treatment of the Arthritis |
| title_full_unstemmed | Metal Complexes and Their Role in Treatment of the Arthritis |
| title_short | Metal Complexes and Their Role in Treatment of the Arthritis |
| title_sort | metal complexes and their role in treatment of the arthritis |
| topic | rheumatoid arthritis metal complexes inflammation nsaids dmars |
| url | https://gazimedj.com/articles/metal-complexes-and-their-role-in-treatment-of-the-arthritis/doi/gmj.2024.3866 |
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