Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes?
Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in the human body and displays many beneficial properties (via reduci...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/136 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841549071030943744 |
|---|---|
| author | Karolina Ogórek Kinga Nowak Emilia Wadych Lena Ruzik Andrei R. Timerbaev Magdalena Matczuk |
| author_facet | Karolina Ogórek Kinga Nowak Emilia Wadych Lena Ruzik Andrei R. Timerbaev Magdalena Matczuk |
| author_sort | Karolina Ogórek |
| collection | DOAJ |
| description | Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in the human body and displays many beneficial properties (via reducing fine lines and wrinkles, tightening skin, improving its elasticity, etc.) is the glycyl-L-histidyl-L-lysine tripeptide complex of copper (GHK–Cu). GHK–Cu is a fairly hydrophilic compound with limited permeation through the lipophilic stratum corneum. On the other hand, liposomes capable of encapsulating GHK–Cu may improve its permeation potential. The present review discusses various issues related to obtaining insight into the permeation of CACs through the skin. Methods for studying the transport of CACs encapsulated by liposomes and free GHK–Cu across the skin barrier are summarized. An analysis of the literature data reveals that the transport of liposomes containing GHK–Cu received little attention. This research gap gives an impetus to the methodological developments for assessing the effect of liposomes on GHK–Cu transportation and trafficking. |
| format | Article |
| id | doaj-art-6827711c8e9e4ff1972b4dca5151e12c |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-6827711c8e9e4ff1972b4dca5151e12c2025-01-10T13:18:59ZengMDPI AGMolecules1420-30492025-01-0130113610.3390/molecules30010136Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes?Karolina Ogórek0Kinga Nowak1Emilia Wadych2Lena Ruzik3Andrei R. Timerbaev4Magdalena Matczuk5Faculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, PolandInstitute of Inorganic Chemistry, University of Vienna; Währinger Str. 42, 1090 Vienna, AustriaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, PolandCosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in the human body and displays many beneficial properties (via reducing fine lines and wrinkles, tightening skin, improving its elasticity, etc.) is the glycyl-L-histidyl-L-lysine tripeptide complex of copper (GHK–Cu). GHK–Cu is a fairly hydrophilic compound with limited permeation through the lipophilic stratum corneum. On the other hand, liposomes capable of encapsulating GHK–Cu may improve its permeation potential. The present review discusses various issues related to obtaining insight into the permeation of CACs through the skin. Methods for studying the transport of CACs encapsulated by liposomes and free GHK–Cu across the skin barrier are summarized. An analysis of the literature data reveals that the transport of liposomes containing GHK–Cu received little attention. This research gap gives an impetus to the methodological developments for assessing the effect of liposomes on GHK–Cu transportation and trafficking.https://www.mdpi.com/1420-3049/30/1/136GHK–Cuskin permeationliposomes |
| spellingShingle | Karolina Ogórek Kinga Nowak Emilia Wadych Lena Ruzik Andrei R. Timerbaev Magdalena Matczuk Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? Molecules GHK–Cu skin permeation liposomes |
| title | Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? |
| title_full | Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? |
| title_fullStr | Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? |
| title_full_unstemmed | Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? |
| title_short | Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? |
| title_sort | are we ready to measure skin permeation of modern antiaging ghk cu tripeptide encapsulated in liposomes |
| topic | GHK–Cu skin permeation liposomes |
| url | https://www.mdpi.com/1420-3049/30/1/136 |
| work_keys_str_mv | AT karolinaogorek arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes AT kinganowak arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes AT emiliawadych arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes AT lenaruzik arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes AT andreirtimerbaev arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes AT magdalenamatczuk arewereadytomeasureskinpermeationofmodernantiagingghkcutripeptideencapsulatedinliposomes |