Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p

Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p

Abstract Background Liver fibrosis is a worldwide disease that develops from activation and propagation of hepatic stellate cells, and subsequent extracellular matrix accumulation. Liver fibrosis is associated with multiple pathways, however, the dysregulation of GIPC1 gene (GIPC PDZ domain containi...

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Bibliographic Details
Main Authors: Rana Mostafa Adel, Sara Mostafa Kamal, Eman Adel Sherif, Sara Hatem El-shafiey
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Curcumin
MMP-8/TIMP-3 balance
miRNA-483-5p
TNF-α
IL-6
TGF-β1
Online Access:https://doi.org/10.1186/s43088-024-00590-x
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