Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A
Bisphenol A (BPA), a chemical compound in plastics and resins, widely exist in people's production and life which have great potential to damage human and animal health. It has been proved that BPA could affect human immune function and promote the occurrence and development of autoimmune disea...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324014283 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846138605990313984 |
|---|---|
| author | Yanggang Hong Deqi Wang Yinfang Lin Qianru Yang Yi Wang Yuanyuan Xie Wanyi Shu Sheng Gao Chunyan Hua |
| author_facet | Yanggang Hong Deqi Wang Yinfang Lin Qianru Yang Yi Wang Yuanyuan Xie Wanyi Shu Sheng Gao Chunyan Hua |
| author_sort | Yanggang Hong |
| collection | DOAJ |
| description | Bisphenol A (BPA), a chemical compound in plastics and resins, widely exist in people's production and life which have great potential to damage human and animal health. It has been proved that BPA could affect human immune function and promote the occurrence and development of autoimmune diseases (ADs). However, the mechanism and pathophysiology remain unknown. Therefore, this study aims to advance network toxicology strategies to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants, focusing on ADs induced by BPA exposure. Leveraging databases including ChEMBL, STITCH, SwissTargetPrediction, GeneCards, and OMIM, we identified potential targets associated with BPA exposure and ADs, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Hashimoto's thyroiditis (HT), inflammatory bowel disease (IBD), and type 1 diabetes (T1D). Subsequent refinement using STRING and Cytoscape software highlighted core targets respectively, and Metascape was utilized for enrichment analysis. Gene expression data from the GEO database revealed the upregulation or downregulation of these targets across these ADs. Molecular docking performed with Autodock confirmed robust binding between BPA and core targets, notably PPARG, CTNNB1, ESR1, EGFR, SRC, and CCND1. These findings suggest that BPA exposure may serve as an environmental trigger in the development of autoimmunity, underscoring potential environmental risk factors for the onset of autoimmune conditions. |
| format | Article |
| id | doaj-art-681bd5c9e45b48a29fae967b7590f1c6 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-681bd5c9e45b48a29fae967b7590f1c62024-12-07T08:24:28ZengElsevierEcotoxicology and Environmental Safety0147-65132024-12-01288117352Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol AYanggang Hong0Deqi Wang1Yinfang Lin2Qianru Yang3Yi Wang4Yuanyuan Xie5Wanyi Shu6Sheng Gao7Chunyan Hua8The Second School of Medicine, Wenzhou Medical University, Zhejiang Province 325035, ChinaThe First School of Medicine, Wenzhou Medical University, Zhejiang Province 325035, ChinaThe First School of Medicine, Wenzhou Medical University, Zhejiang Province 325035, ChinaThe First School of Medicine, Wenzhou Medical University, Zhejiang Province 325035, ChinaThe First School of Medicine, Wenzhou Medical University, Zhejiang Province 325035, ChinaSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, ChinaSchool of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, ChinaLaboratory Animal Center, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, China; Corresponding authors.School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, China; Corresponding authors.Bisphenol A (BPA), a chemical compound in plastics and resins, widely exist in people's production and life which have great potential to damage human and animal health. It has been proved that BPA could affect human immune function and promote the occurrence and development of autoimmune diseases (ADs). However, the mechanism and pathophysiology remain unknown. Therefore, this study aims to advance network toxicology strategies to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants, focusing on ADs induced by BPA exposure. Leveraging databases including ChEMBL, STITCH, SwissTargetPrediction, GeneCards, and OMIM, we identified potential targets associated with BPA exposure and ADs, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Hashimoto's thyroiditis (HT), inflammatory bowel disease (IBD), and type 1 diabetes (T1D). Subsequent refinement using STRING and Cytoscape software highlighted core targets respectively, and Metascape was utilized for enrichment analysis. Gene expression data from the GEO database revealed the upregulation or downregulation of these targets across these ADs. Molecular docking performed with Autodock confirmed robust binding between BPA and core targets, notably PPARG, CTNNB1, ESR1, EGFR, SRC, and CCND1. These findings suggest that BPA exposure may serve as an environmental trigger in the development of autoimmunity, underscoring potential environmental risk factors for the onset of autoimmune conditions.http://www.sciencedirect.com/science/article/pii/S0147651324014283Bisphenol AAutoimmune diseasesNetwork toxicologyMolecular dockingEnvironmental exposure |
| spellingShingle | Yanggang Hong Deqi Wang Yinfang Lin Qianru Yang Yi Wang Yuanyuan Xie Wanyi Shu Sheng Gao Chunyan Hua Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A Ecotoxicology and Environmental Safety Bisphenol A Autoimmune diseases Network toxicology Molecular docking Environmental exposure |
| title | Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A |
| title_full | Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A |
| title_fullStr | Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A |
| title_full_unstemmed | Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A |
| title_short | Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A |
| title_sort | environmental triggers and future risk of developing autoimmune diseases molecular mechanism and network toxicology analysis of bisphenol a |
| topic | Bisphenol A Autoimmune diseases Network toxicology Molecular docking Environmental exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324014283 |
| work_keys_str_mv | AT yangganghong environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT deqiwang environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT yinfanglin environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT qianruyang environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT yiwang environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT yuanyuanxie environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT wanyishu environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT shenggao environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola AT chunyanhua environmentaltriggersandfutureriskofdevelopingautoimmunediseasesmolecularmechanismandnetworktoxicologyanalysisofbisphenola |