2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator
The phagocytic activities of various immune cells can be enhanced by the use of medicinal preparations that can confer physiological homeostasis through the elimination of both pathogenic material and cells experiencing apoptosis. Nevertheless, studies on the achievement of this kind of reaction by...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cogent Food & Agriculture |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/23311932.2024.2413399 |
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| author | Eman T. Ali Hussein N. K. Al-Salman Majid S. Jabir Ghassan M. Sulaiman Hamdoon A. Mohammed Mosleh M. Abomughaid |
| author_facet | Eman T. Ali Hussein N. K. Al-Salman Majid S. Jabir Ghassan M. Sulaiman Hamdoon A. Mohammed Mosleh M. Abomughaid |
| author_sort | Eman T. Ali |
| collection | DOAJ |
| description | The phagocytic activities of various immune cells can be enhanced by the use of medicinal preparations that can confer physiological homeostasis through the elimination of both pathogenic material and cells experiencing apoptosis. Nevertheless, studies on the achievement of this kind of reaction by the use of 2-(benzhydrylsulfinyl)-N-sec-butylacetamide as a novel derivative are seldom. Hence, we assess herein the impacts of this novel compound on macrophage cells (RAW 264.7) involved in phagocytic activities as well as on the growth of Gram-negative Escherichia coli (E. coli). A significant increase in both phagocytosis and bactericidal activities was observed, as indicated by the fact that E. coli was remarkably cleared in response to the treatment. In parallel, a highly significant increase (p < 0.0001) in the size of the cell, particularly the cytoplasm, was recorded. Additional analyses revealed that 2-(benzhydrylsulfinyl)-N-sec-butylacetamide derived from fig significantly modulates the levels of the inflammatory cytokines such as tumour necrosis factor α (TNF-α), Interleukin (IL) -2, IL-1ß, and IL-17 in the RAW 264.7 macrophage cell culture supernatants. Taken together, 2-(benzhydrylsulfinyl)-N-sec-butylacetamide could enhance the phagocytic activity of phagocytic cells through increasing the inflammatory mediators, reactive oxygen species (ROS), and cell size. |
| format | Article |
| id | doaj-art-67ce16c7b8f242a689cd45d2df1d1f16 |
| institution | Kabale University |
| issn | 2331-1932 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Food & Agriculture |
| spelling | doaj-art-67ce16c7b8f242a689cd45d2df1d1f162024-12-13T09:52:53ZengTaylor & Francis GroupCogent Food & Agriculture2331-19322024-12-0110110.1080/23311932.2024.24133992-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulatorEman T. Ali0Hussein N. K. Al-Salman1Majid S. Jabir2Ghassan M. Sulaiman3Hamdoon A. Mohammed4Mosleh M. Abomughaid5Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Basrah, IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Basrah, IraqDivision of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, IraqDivision of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, IraqDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha,Saudi ArabiaThe phagocytic activities of various immune cells can be enhanced by the use of medicinal preparations that can confer physiological homeostasis through the elimination of both pathogenic material and cells experiencing apoptosis. Nevertheless, studies on the achievement of this kind of reaction by the use of 2-(benzhydrylsulfinyl)-N-sec-butylacetamide as a novel derivative are seldom. Hence, we assess herein the impacts of this novel compound on macrophage cells (RAW 264.7) involved in phagocytic activities as well as on the growth of Gram-negative Escherichia coli (E. coli). A significant increase in both phagocytosis and bactericidal activities was observed, as indicated by the fact that E. coli was remarkably cleared in response to the treatment. In parallel, a highly significant increase (p < 0.0001) in the size of the cell, particularly the cytoplasm, was recorded. Additional analyses revealed that 2-(benzhydrylsulfinyl)-N-sec-butylacetamide derived from fig significantly modulates the levels of the inflammatory cytokines such as tumour necrosis factor α (TNF-α), Interleukin (IL) -2, IL-1ß, and IL-17 in the RAW 264.7 macrophage cell culture supernatants. Taken together, 2-(benzhydrylsulfinyl)-N-sec-butylacetamide could enhance the phagocytic activity of phagocytic cells through increasing the inflammatory mediators, reactive oxygen species (ROS), and cell size.https://www.tandfonline.com/doi/10.1080/23311932.2024.24133992-(Benzhydrylsulfinyl)-N-sec-butylacetamide)immune modulator macrophagephagocytosiscytokinesoxidative stressanti-inflammatory |
| spellingShingle | Eman T. Ali Hussein N. K. Al-Salman Majid S. Jabir Ghassan M. Sulaiman Hamdoon A. Mohammed Mosleh M. Abomughaid 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator Cogent Food & Agriculture 2-(Benzhydrylsulfinyl)-N-sec-butylacetamide) immune modulator macrophage phagocytosis cytokines oxidative stress anti-inflammatory |
| title | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator |
| title_full | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator |
| title_fullStr | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator |
| title_full_unstemmed | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator |
| title_short | 2-(Benzhydryl sulfinyl)-N-sec-butylacetamide isolated from fig fruits as a potential immune response modulator |
| title_sort | 2 benzhydryl sulfinyl n sec butylacetamide isolated from fig fruits as a potential immune response modulator |
| topic | 2-(Benzhydrylsulfinyl)-N-sec-butylacetamide) immune modulator macrophage phagocytosis cytokines oxidative stress anti-inflammatory |
| url | https://www.tandfonline.com/doi/10.1080/23311932.2024.2413399 |
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