The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis

Mycobacterium avium complex, a commonly seen infection in individuals with a compromised immune system, can also affect people who are immunocompetent. One particularly important manifestation is in elderly females with a competent immune system, involving the middle lobe and lingula lobe of the lun...

Full description

Saved in:
Bibliographic Details
Main Authors: Muhammad Ammar, Muhammad Salman Ullah, Rana Uzair Ahmad, Tabraiz Hassan Tanvir, Maria Rehmani
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Radiology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043324011786
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1846167115350933504
author Muhammad Ammar
Muhammad Salman Ullah
Rana Uzair Ahmad
Tabraiz Hassan Tanvir
Maria Rehmani
author_facet Muhammad Ammar
Muhammad Salman Ullah
Rana Uzair Ahmad
Tabraiz Hassan Tanvir
Maria Rehmani
author_sort Muhammad Ammar
collection DOAJ
description Mycobacterium avium complex, a commonly seen infection in individuals with a compromised immune system, can also affect people who are immunocompetent. One particularly important manifestation is in elderly females with a competent immune system, involving the middle lobe and lingula lobe of the lung. This is known as Lady Windermere syndrome (LWS). An 84-year-old female patient with certain nonpulmonary comorbidities initially got a diagnosis of MAC infection but refused to undergo any medication therapy, she presents after 5 years for a follow up visit and is found to have significant changes in her pulmonary parenchyma on investigation findings, concerning for this syndrome. LWS is a rather uncommon condition, rarely presents in clinical settings and described very less often in the literature. This report is aimed at increasing awareness of LWS as a possible diagnosis that should be considered in patients with a chronic MAC infection and a specific pattern of parenchymal changes discussed in this report in detail.
format Article
id doaj-art-67b236f334654981b2e3ddbaebd08b48
institution Kabale University
issn 1930-0433
language English
publishDate 2025-01-01
publisher Elsevier
record_format Article
series Radiology Case Reports
spelling doaj-art-67b236f334654981b2e3ddbaebd08b482024-11-15T06:11:37ZengElsevierRadiology Case Reports1930-04332025-01-01201747751The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosisMuhammad Ammar0Muhammad Salman Ullah1Rana Uzair Ahmad2Tabraiz Hassan Tanvir3Maria Rehmani4Mayo hospital, Anarkali, Lahore, 54000, Punjab, PakistanMayo hospital, Anarkali, Lahore, 54000, Punjab, PakistanCorresponding author.; Mayo hospital, Anarkali, Lahore, 54000, Punjab, PakistanMayo hospital, Anarkali, Lahore, 54000, Punjab, PakistanMayo hospital, Anarkali, Lahore, 54000, Punjab, PakistanMycobacterium avium complex, a commonly seen infection in individuals with a compromised immune system, can also affect people who are immunocompetent. One particularly important manifestation is in elderly females with a competent immune system, involving the middle lobe and lingula lobe of the lung. This is known as Lady Windermere syndrome (LWS). An 84-year-old female patient with certain nonpulmonary comorbidities initially got a diagnosis of MAC infection but refused to undergo any medication therapy, she presents after 5 years for a follow up visit and is found to have significant changes in her pulmonary parenchyma on investigation findings, concerning for this syndrome. LWS is a rather uncommon condition, rarely presents in clinical settings and described very less often in the literature. This report is aimed at increasing awareness of LWS as a possible diagnosis that should be considered in patients with a chronic MAC infection and a specific pattern of parenchymal changes discussed in this report in detail.http://www.sciencedirect.com/science/article/pii/S1930043324011786
spellingShingle Muhammad Ammar
Muhammad Salman Ullah
Rana Uzair Ahmad
Tabraiz Hassan Tanvir
Maria Rehmani
The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
Radiology Case Reports
title The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
title_full The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
title_fullStr The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
title_full_unstemmed The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
title_short The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis
title_sort subtle evolution of pulmonary parenchymal changes a case of lady windermere syndrome emerging from chronic mac infection in an immunocompetent patient with scoliosis
url http://www.sciencedirect.com/science/article/pii/S1930043324011786
work_keys_str_mv AT muhammadammar thesubtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT muhammadsalmanullah thesubtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT ranauzairahmad thesubtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT tabraizhassantanvir thesubtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT mariarehmani thesubtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT muhammadammar subtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT muhammadsalmanullah subtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT ranauzairahmad subtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT tabraizhassantanvir subtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis
AT mariarehmani subtleevolutionofpulmonaryparenchymalchangesacaseofladywindermeresyndromeemergingfromchronicmacinfectioninanimmunocompetentpatientwithscoliosis