Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma
Introduction: There is little information in the literature on the early, sub-clinical stage and laboratory test results in patients with primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lung, a rare disease. Case description: In a 75-year-old man, an open lung biopsy-confirmed diagn...
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| Language: | English |
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SMC MEDIA SRL
2024-12-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/4997 |
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| author | Ami Schattner Ariel Rokach Fiona Vernea Maria Spector Kalman Filanovsky |
| author_facet | Ami Schattner Ariel Rokach Fiona Vernea Maria Spector Kalman Filanovsky |
| author_sort | Ami Schattner |
| collection | DOAJ |
| description | Introduction: There is little information in the literature on the early, sub-clinical stage and laboratory test results in patients with primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lung, a rare disease.
Case description: In a 75-year-old man, an open lung biopsy-confirmed diagnosis of primary pulmonary lymphoma was preceded by almost six months of anaemia of inflammatory disease and monocytosis without any pulmonary symptoms. When he developed a dry cough, increasing dyspnoea and marked weight loss, these changes deepened and became associated with reactive thrombocytosis; markedly increased ferritin and C-reactive protein (positive acute-phase reactants), as well as reduced albumin and transferrin (negative acute-phase reactants). Globulins increased, due to an increase in the alpha1, alpha2 and gamma fractions, and mild hyponatraemia developed due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) secondary to the intrathoracic disease. All these changes were completely reversible following successful treatment and complete remission.
Conclusion: The previously unreported detailed laboratory features of early, sub-clinical and advanced primary pulmonary lymphoma are presented. When a potentially susceptible patient develops an unexplained anaemia of inflammatory disease, primary pulmonary lymphoma should be added to the differential diagnosis. |
| format | Article |
| id | doaj-art-678c410cd3ac4123ab0417978435ee90 |
| institution | Kabale University |
| issn | 2284-2594 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-678c410cd3ac4123ab0417978435ee902025-01-07T13:40:28ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942024-12-0110.12890/2024_0049974532Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphomaAmi Schattner0Ariel Rokach1Fiona Vernea2Maria Spector3Kalman Filanovsky4The Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, IsraelThe Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel; Departments of Pulmonology (AR), Pathology (FV) and Imaging (MS), Shaare Zedek Medical Center, Jerusalem, IsraelThe Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel; Departments of Pulmonology (AR), Pathology (FV) and Imaging (MS), Shaare Zedek Medical Center, Jerusalem, IsraelThe Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel; Departments of Pulmonology (AR), Pathology (FV) and Imaging (MS), Shaare Zedek Medical Center, Jerusalem, IsraelThe Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel; Institute of Hematology (KF), Kaplan Medical Center, Rehovot, IsraelIntroduction: There is little information in the literature on the early, sub-clinical stage and laboratory test results in patients with primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lung, a rare disease. Case description: In a 75-year-old man, an open lung biopsy-confirmed diagnosis of primary pulmonary lymphoma was preceded by almost six months of anaemia of inflammatory disease and monocytosis without any pulmonary symptoms. When he developed a dry cough, increasing dyspnoea and marked weight loss, these changes deepened and became associated with reactive thrombocytosis; markedly increased ferritin and C-reactive protein (positive acute-phase reactants), as well as reduced albumin and transferrin (negative acute-phase reactants). Globulins increased, due to an increase in the alpha1, alpha2 and gamma fractions, and mild hyponatraemia developed due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) secondary to the intrathoracic disease. All these changes were completely reversible following successful treatment and complete remission. Conclusion: The previously unreported detailed laboratory features of early, sub-clinical and advanced primary pulmonary lymphoma are presented. When a potentially susceptible patient develops an unexplained anaemia of inflammatory disease, primary pulmonary lymphoma should be added to the differential diagnosis.https://www.ejcrim.com/index.php/EJCRIM/article/view/4997primary pulmonary lymphoma diagnosisanaemia of inflammationmonocytosisprimary pulmonary lymphomahyperferritinaemia |
| spellingShingle | Ami Schattner Ariel Rokach Fiona Vernea Maria Spector Kalman Filanovsky Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma European Journal of Case Reports in Internal Medicine primary pulmonary lymphoma diagnosis anaemia of inflammation monocytosis primary pulmonary lymphoma hyperferritinaemia |
| title | Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma |
| title_full | Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma |
| title_fullStr | Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma |
| title_full_unstemmed | Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma |
| title_short | Anaemia of inflammation preceding dyspnoea, dry cough and weight loss in primary pulmonary lymphoma |
| title_sort | anaemia of inflammation preceding dyspnoea dry cough and weight loss in primary pulmonary lymphoma |
| topic | primary pulmonary lymphoma diagnosis anaemia of inflammation monocytosis primary pulmonary lymphoma hyperferritinaemia |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/4997 |
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