Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms
We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000731 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524547207036928 |
|---|---|
| author | S. Sipka T. Seres Z. Dinya Z. Szekanecz J. Szentmiklósi E. Bodolay G. Szegedi |
| author_facet | S. Sipka T. Seres Z. Dinya Z. Szekanecz J. Szentmiklósi E. Bodolay G. Szegedi |
| author_sort | S. Sipka |
| collection | DOAJ |
| description | We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-10. We suggest that these cytokines may contribute to the terminal SIRS-related arrythmias, impaired myocardial contractility, as well as increased vascular permeability. In addition, the increased production of adenosine, a counter-regulatory mediator of inflammation, may also play a role in cardiodepression. We suggest a relationship between the action of TNF-α , IL-10 and adenosine in the pathogenesis of circulatory symptoms described above. |
| format | Article |
| id | doaj-art-678c041c41914fbc9be9d12d9090d2bd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-678c041c41914fbc9be9d12d9090d2bd2025-02-03T05:52:54ZengWileyMediators of Inflammation0962-93511466-18611995-01-014645445510.1155/S0962935195000731Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptomsS. Sipka0T. Seres1Z. Dinya2Z. Szekanecz3J. Szentmiklósi4E. Bodolay5G. Szegedi6Third Department of Medicine, University Mdical School, HungaryThird Department of Medicine, University Mdical School, HungaryDepartment of Orgaic Chemistry, Lajos Kossuth University, Debrecen, HungaryThird Department of Medicine, University Mdical School, HungaryDepartment of Pharmacology, University Mdical School, HungaryThird Department of Medicine, University Mdical School, HungaryThird Department of Medicine, University Mdical School, HungaryWe have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-10. We suggest that these cytokines may contribute to the terminal SIRS-related arrythmias, impaired myocardial contractility, as well as increased vascular permeability. In addition, the increased production of adenosine, a counter-regulatory mediator of inflammation, may also play a role in cardiodepression. We suggest a relationship between the action of TNF-α , IL-10 and adenosine in the pathogenesis of circulatory symptoms described above.http://dx.doi.org/10.1155/S0962935195000731 |
| spellingShingle | S. Sipka T. Seres Z. Dinya Z. Szekanecz J. Szentmiklósi E. Bodolay G. Szegedi Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms Mediators of Inflammation |
| title | Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| title_full | Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| title_fullStr | Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| title_full_unstemmed | Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| title_short | Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| title_sort | tumour necrosis factor α and adenosine in endotoxin shockleading related cardiovascular symptoms |
| url | http://dx.doi.org/10.1155/S0962935195000731 |
| work_keys_str_mv | AT ssipka tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT tseres tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT zdinya tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT zszekanecz tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT jszentmiklosi tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT ebodolay tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms AT gszegedi tumournecrosisfactoraandadenosineinendotoxinshockleadingrelatedcardiovascularsymptoms |