Effects of Jintiange on the healing of osteoporotic fractures in aged rats
Abstract Objective To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats. Methods An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a co...
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BMC
2024-12-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-024-05351-1 |
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| author | Jie Liu Ting-Ting Liu Hai-Cheng Zhang Chen Li Wei Wei Ai-Jun Chao |
| author_facet | Jie Liu Ting-Ting Liu Hai-Cheng Zhang Chen Li Wei Wei Ai-Jun Chao |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Abstract Objective To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats. Methods An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a control group, each with an equal sample size (n = 35). The experimental group received Jintiange capsule ingredients via intragastric administration, while the control group received an equal volume of saline via the same method. X-ray examinations were conducted at the 4th and 12th weeks to evaluate fracture healing in the rats. After 12 weeks, micro-CT scanning was employed to assess the microstructure of the healthy femurs, and the parameters of the experimental and control groups were compared. Results After 4 weeks, the mean fracture healing scores were 0.78 ± 0.43 in the experimental group and 0.56 ± 0.51 in the control group. After 12 weeks, the mean scores were 1.50 ± 0.71 in the experimental group and 0.96 ± 0.68 in the control group. The scores in the experimental group were higher than those in the control group (P < 0.05). Micro-CT examination of the femurs showed an improvement trend in bone microarchitecture in the experimental group, indicated by increased bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th). However, these improvements were not statistically significant. A negative correlation with statistical significance was observed between trabecular separation (Tb. Sp) and fracture healing scores. Conclusions Jintiange may promote osteoporotic fracture healing in aged rats by enhancing bone microstructure. |
| format | Article |
| id | doaj-art-678adec00c184adf84b5b88891371ddc |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-678adec00c184adf84b5b88891371ddc2024-12-22T12:37:22ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2024-12-011911810.1186/s13018-024-05351-1Effects of Jintiange on the healing of osteoporotic fractures in aged ratsJie Liu0Ting-Ting Liu1Hai-Cheng Zhang2Chen Li3Wei Wei4Ai-Jun Chao5Department of Rheumatology and Immunology, Tianjin Medical University General HospitalDepartment of Osteo-internal Medicine, Tianjin HospitalDepartment of Osteo-internal Medicine, Tianjin HospitalDepartment of Orthopaedics, Tianjin HospitalDepartment of Rheumatology and Immunology, Tianjin Medical University General HospitalDepartment of Osteo-internal Medicine, Tianjin HospitalAbstract Objective To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats. Methods An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a control group, each with an equal sample size (n = 35). The experimental group received Jintiange capsule ingredients via intragastric administration, while the control group received an equal volume of saline via the same method. X-ray examinations were conducted at the 4th and 12th weeks to evaluate fracture healing in the rats. After 12 weeks, micro-CT scanning was employed to assess the microstructure of the healthy femurs, and the parameters of the experimental and control groups were compared. Results After 4 weeks, the mean fracture healing scores were 0.78 ± 0.43 in the experimental group and 0.56 ± 0.51 in the control group. After 12 weeks, the mean scores were 1.50 ± 0.71 in the experimental group and 0.96 ± 0.68 in the control group. The scores in the experimental group were higher than those in the control group (P < 0.05). Micro-CT examination of the femurs showed an improvement trend in bone microarchitecture in the experimental group, indicated by increased bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th). However, these improvements were not statistically significant. A negative correlation with statistical significance was observed between trabecular separation (Tb. Sp) and fracture healing scores. Conclusions Jintiange may promote osteoporotic fracture healing in aged rats by enhancing bone microstructure.https://doi.org/10.1186/s13018-024-05351-1AgedBone microstructureFracture healingJintiangeOsteoporosis |
| spellingShingle | Jie Liu Ting-Ting Liu Hai-Cheng Zhang Chen Li Wei Wei Ai-Jun Chao Effects of Jintiange on the healing of osteoporotic fractures in aged rats Journal of Orthopaedic Surgery and Research Aged Bone microstructure Fracture healing Jintiange Osteoporosis |
| title | Effects of Jintiange on the healing of osteoporotic fractures in aged rats |
| title_full | Effects of Jintiange on the healing of osteoporotic fractures in aged rats |
| title_fullStr | Effects of Jintiange on the healing of osteoporotic fractures in aged rats |
| title_full_unstemmed | Effects of Jintiange on the healing of osteoporotic fractures in aged rats |
| title_short | Effects of Jintiange on the healing of osteoporotic fractures in aged rats |
| title_sort | effects of jintiange on the healing of osteoporotic fractures in aged rats |
| topic | Aged Bone microstructure Fracture healing Jintiange Osteoporosis |
| url | https://doi.org/10.1186/s13018-024-05351-1 |
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