E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and type 2 immune response in the murine lung

E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and type 2 immune response in the murine lung

Abstract Allergic airway inflammation is a universal airway disease induced by inhaling allergens. Published data show that RNF128, an E3 ligase, promotes Th2 activation in the OVA-induced asthma model. Recent advances have shown that group 2 innate lymphoid cells (ILC2s) produce the cytokines IL-5...

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Bibliographic Details
Main Authors: Chenghua Yan, Wendong Kuang, Guangqiang Ma, Feifei Guo, Liang Jin, Hongjiao Wan, Jinhua Zhu, Yongcui Liao, Haijun Tan, Liyuan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
E3 ligase RNF128
Group 2 innate lymphoid cells
Allergic lung inflammation
Online Access:https://doi.org/10.1038/s41598-025-85227-4
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