PPAR-γ agonist mitigates intestinal barrier dysfunction and inflammation induced by Clostridioides difficile SlpA in vitro

PPAR-γ agonist mitigates intestinal barrier dysfunction and inflammation induced by Clostridioides difficile SlpA in vitro

Abstract Clostridioides difficile is the leading cause of healthcare- and antibiotic-associated diarrhea. Surface layer protein A (SlpA), an essential component of the bacterium’s outermost layer, contributes to colonization and inflammation. The peroxisome proliferator-activated receptor gamma (PPA...

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Bibliographic Details
Main Authors: Maryam Noori, Masoumeh Azimirad, Mahsa Ghorbaninejad, Anna Meyfour, Mohammad Reza Zali, Abbas Yadegar
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Clostridioides difficile
Surface layer protein A
Peroxisome proliferator-activated receptor gamma
Caco-2 cells
THP-1 derived macrophages
Pioglitazone
Online Access:https://doi.org/10.1038/s41598-024-83815-4
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