Recent Improvements in the Pathogenesis of Atopic Dermatitis
Atopic dermatitis (AD) is a multifactorial skin disease manifested by the interaction between environmental factors, immune system and the genes predisposing to the disease. It affects the quality of life of patients and their family considerably. The prevelance for children is 10-20% in develope...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2015-12-01
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| Series: | Güncel Pediatri |
| Subjects: | |
| Online Access: | http://www.guncelpediatri.com/article_10505/Recent-Improvements-In-The-Pathogenesis-Of-Atopic-Dermatitis |
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| Summary: | Atopic dermatitis (AD) is a multifactorial skin disease manifested by the interaction
between environmental factors, immune system and the genes predisposing to the
disease. It affects the quality of life of patients and their family considerably. The
prevelance for children is 10-20% in developed countries, while frequency of AD
is considered as rising all over the world. According to the studies conducted in
our country, the frequency is about 4.9% to 8.1%. Currently, there are two main
hypothesis accepted to explain disease pathogenesis; inside-outside and outsideinside
hypotheses. However, these are even not able to define the pathogenetic
mechanisms underlying AD in all details. In the recent years, genetic studies have
revealed significant role of filaggrin gene in the pathogenesis of AD. Further,
epidermal barier dysfunction is found to play an important role in the pathogenesis
by causing dryness and pruritus in skin and cause predisposition to infections with
some viruses and bacteria. In this review, recent data about genetic, immunologic
mechanisms and the dysfunction of epidermal barier complex underlying the
pathogenesis of AD will be discussed. |
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| ISSN: | 1304-9054 |