Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α

Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α

Background: As the primary source of glucose during fasting, hepatic gluconeogenesis is rigorously regulated to maintain euglycemia. Abnormal gluconeogenesis in the liver can lead to hyperglycemia, a key diagnostic marker and the primary pathological contributor to type 2 diabetes (T2D) and metaboli...

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Bibliographic Details
Main Authors: Xiaomin Luo, Fang Liu, Lijun Zhu, Caizhi Liu, Ruhui Shen, Xiaoyin Ding, Yufan Wang, Xiaofang Tang, Yongde Peng, Zhijian Zhang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
Gluconeogenesis
Hepatic nuclear factor 4α
Leupaxin
Glucose metabolism
Metabolic disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002060
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