Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease

Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease

Abstract Background Peripheral arterial disease (PAD) is a leading cause of limb disability due to ischemia caused by atherosclerotic plaques. Cell-based therapies using endothelial cells (ECs) have shown promise in promoting angiogenesis for PAD, but challenges remain in obtaining sufficient ECs fr...

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Bibliographic Details
Main Authors: Jungju Choi, Nam Gyo Kim, Dasom Kong, Min-Ji Kim, Byeong-Cheol Kang, Daekee Kwon, Da-Hyun Kim, Kyung-Sun Kang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Hypoimmunogenic iPSCs
Endothelial cells
Angiogenesis
Humanized mouse
Hindlimb ischemia
Immune response
Online Access:https://doi.org/10.1186/s13287-025-04554-5
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