Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China
Background: While much of the evidence linking the rapid urbanization and the increasing prevalence of allergen sensitization, but little is known regarding rural-to-urban migrants. The aim of this study was to identify the disparities in allergy, the gut microbiome and factors among native urban, m...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001509 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526275994288128 |
|---|---|
| author | Wanjun Wang Mo Xian Ruchong Chen Jing Li Lulu Wu |
| author_facet | Wanjun Wang Mo Xian Ruchong Chen Jing Li Lulu Wu |
| author_sort | Wanjun Wang |
| collection | DOAJ |
| description | Background: While much of the evidence linking the rapid urbanization and the increasing prevalence of allergen sensitization, but little is known regarding rural-to-urban migrants. The aim of this study was to identify the disparities in allergy, the gut microbiome and factors among native urban, migrating, and native rural Chinese. Methods: We redesigned the dataset of the China Alliance of Research on Respiratory Allergic Disease secondary survey, and after stratified sampling, a subsample of 2422 subjects were enrolled for the analysis of a questionnaire, skin prick tests (SPT), and specific immunoglobulin E (sIgE) titer measurements against 8 common allergens. Fecal microbiotal composition was also sequenced by 16S rRNA and regression-based analyses with covariate adjustment applied. Results: From urban to migrant and rural populations, IgE sensitization was predominantly directed against Dermatophagoides pteronyssinus (Der p). The titers of Der p-sIgE decreased sequentially across the 3 respective populations and co-sensitization to other allergens also showed a sequential decrease. Rural-to-urban migrants showed a low prevalence of Der p-SPT and Der p-sIgE initially, but developed substantial IgE titers and their gut microbiotal diversity, as well as species richness, appeared to change along with residential time spent in the urban area. High-fat diet, using a mattress, an SPT wheal size from Der p ≥ 6 mm, and duration of immigration >5 years were significantly associated with sIgE positivity in the migrants. Conclusion: The Der p-sIgE responses and the composition of gut microbiota differs synchronously with extended living time in an urban area. Studies in immigrants provide a unique opportunities to evaluate the effects of environmental factors in the pathogenesis of allergic disorders. |
| format | Article |
| id | doaj-art-66cfb14a14234e448549a3b004f8d346 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-66cfb14a14234e448549a3b004f8d3462025-01-17T04:49:16ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181101018Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across ChinaWanjun Wang0Mo Xian1Ruchong Chen2Jing Li3Lulu Wu4Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, ChinaDepartment of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, ChinaDepartment of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, ChinaDepartment of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, ChinaDepartment of Respiratory Medicine, Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, China; Corresponding author. Guangzhou Institute of Respiratory Health, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.Background: While much of the evidence linking the rapid urbanization and the increasing prevalence of allergen sensitization, but little is known regarding rural-to-urban migrants. The aim of this study was to identify the disparities in allergy, the gut microbiome and factors among native urban, migrating, and native rural Chinese. Methods: We redesigned the dataset of the China Alliance of Research on Respiratory Allergic Disease secondary survey, and after stratified sampling, a subsample of 2422 subjects were enrolled for the analysis of a questionnaire, skin prick tests (SPT), and specific immunoglobulin E (sIgE) titer measurements against 8 common allergens. Fecal microbiotal composition was also sequenced by 16S rRNA and regression-based analyses with covariate adjustment applied. Results: From urban to migrant and rural populations, IgE sensitization was predominantly directed against Dermatophagoides pteronyssinus (Der p). The titers of Der p-sIgE decreased sequentially across the 3 respective populations and co-sensitization to other allergens also showed a sequential decrease. Rural-to-urban migrants showed a low prevalence of Der p-SPT and Der p-sIgE initially, but developed substantial IgE titers and their gut microbiotal diversity, as well as species richness, appeared to change along with residential time spent in the urban area. High-fat diet, using a mattress, an SPT wheal size from Der p ≥ 6 mm, and duration of immigration >5 years were significantly associated with sIgE positivity in the migrants. Conclusion: The Der p-sIgE responses and the composition of gut microbiota differs synchronously with extended living time in an urban area. Studies in immigrants provide a unique opportunities to evaluate the effects of environmental factors in the pathogenesis of allergic disorders.http://www.sciencedirect.com/science/article/pii/S1939455124001509AllergensEnvironmentGut microbiotaImmigrantImmunoglobulin E |
| spellingShingle | Wanjun Wang Mo Xian Ruchong Chen Jing Li Lulu Wu Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China World Allergy Organization Journal Allergens Environment Gut microbiota Immigrant Immunoglobulin E |
| title | Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China |
| title_full | Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China |
| title_fullStr | Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China |
| title_full_unstemmed | Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China |
| title_short | Gradient disparities in allergy and the gut microbiome among rural, migrant, and urban populations across China |
| title_sort | gradient disparities in allergy and the gut microbiome among rural migrant and urban populations across china |
| topic | Allergens Environment Gut microbiota Immigrant Immunoglobulin E |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001509 |
| work_keys_str_mv | AT wanjunwang gradientdisparitiesinallergyandthegutmicrobiomeamongruralmigrantandurbanpopulationsacrosschina AT moxian gradientdisparitiesinallergyandthegutmicrobiomeamongruralmigrantandurbanpopulationsacrosschina AT ruchongchen gradientdisparitiesinallergyandthegutmicrobiomeamongruralmigrantandurbanpopulationsacrosschina AT jingli gradientdisparitiesinallergyandthegutmicrobiomeamongruralmigrantandurbanpopulationsacrosschina AT luluwu gradientdisparitiesinallergyandthegutmicrobiomeamongruralmigrantandurbanpopulationsacrosschina |