High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits

High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits

ABSTRACT Genome-wide association studies (GWAS) with binary or single phenotype data have successfully identified disease-associated genotypes and determinants of antimicrobial resistance. We describe a novel phenotype-to-genotype approach for a major bacterial pathogen that involves simultaneously...

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Main Authors: Robeena Farzand, Mercy W. Kimani, Evangelos Mourkas, Abdullahi Jama, Jack L. Clark, Megan De Ste Croix, William M. Monteith, Jay Lucidarme, Neil J. Oldfield, David P. J. Turner, Ray Borrow, Luisa Martinez-Pomares, Samuel K. Sheppard, Christopher D. Bayliss
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mBio
Subjects:
GWAS
phase variation
Neisseria meningitidis
genotype-to-phenotype
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03059-24
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https://journals.asm.org/doi/10.1128/mbio.03059-24

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