Biochemical synthesis of taxanes from mevalonate

Biochemical synthesis of taxanes from mevalonate

Taxanes are kinds of diterpenoids with important bioactivities, such as paclitaxel (taxol®) is an excellent natural broad-spectrum anticancer drug. Attempts to biosynthesize taxanes have made with limited success, mainly due to the bottleneck of the low efficiency catalytic elements. In this study,...

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Bibliographic Details
Main Authors: Jing Li, Xiaonan Liu, Xiaoxi Zhu, Jiayu Liu, Lei Zhang, Nida Ahmed, Jian Qi, Bihuan Chen, Daliang Tang, Jinsheng Yu, Zhijin Fan, Huifeng Jiang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Biochemical synthesis
Taxanes
Paclitaxel
Modular synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X2400070X
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