Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies
Atomically precise gold nanoclusters (AuNCs) exhibit unique physical and optical properties, making them highly promising for targeted cancer therapy. Their small size enhances cellular uptake, facilitates rapid distribution to tumor tissues, and minimizes accumulation in non-target organs compared...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/1/39 |
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| author | Zoey A. Lockwood Michael R. Jirousek James P. Basilion Clemens Burda |
| author_facet | Zoey A. Lockwood Michael R. Jirousek James P. Basilion Clemens Burda |
| author_sort | Zoey A. Lockwood |
| collection | DOAJ |
| description | Atomically precise gold nanoclusters (AuNCs) exhibit unique physical and optical properties, making them highly promising for targeted cancer therapy. Their small size enhances cellular uptake, facilitates rapid distribution to tumor tissues, and minimizes accumulation in non-target organs compared to larger gold nanoparticles. AuNCs, particularly Au<sub>25</sub>, show significant potential in phototherapy, including photothermal (PTT), photodynamic (PDT), and radiation therapies. These therapies benefit with minimal damage to surrounding healthy tissue. AuNCs also demonstrate excellent stability and biocompatibility, crucial for their effective use in clinical applications. Recent advances in the synthesis and functionalization of AuNCs have further improved their therapeutic efficacy, making them versatile agents for enhancing cancer treatment outcomes. Ongoing research aims to better understand their pharmacokinetics, biodistribution, and long-term safety, paving the way for their broader application in advanced cancer therapies. |
| format | Article |
| id | doaj-art-665864ddd2a749239c966a9858dac049 |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-665864ddd2a749239c966a9858dac0492025-01-10T13:19:20ZengMDPI AGNanomaterials2079-49912024-12-011513910.3390/nano15010039Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer TherapiesZoey A. Lockwood0Michael R. Jirousek1James P. Basilion2Clemens Burda3Department of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Radiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Chemistry, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USAAtomically precise gold nanoclusters (AuNCs) exhibit unique physical and optical properties, making them highly promising for targeted cancer therapy. Their small size enhances cellular uptake, facilitates rapid distribution to tumor tissues, and minimizes accumulation in non-target organs compared to larger gold nanoparticles. AuNCs, particularly Au<sub>25</sub>, show significant potential in phototherapy, including photothermal (PTT), photodynamic (PDT), and radiation therapies. These therapies benefit with minimal damage to surrounding healthy tissue. AuNCs also demonstrate excellent stability and biocompatibility, crucial for their effective use in clinical applications. Recent advances in the synthesis and functionalization of AuNCs have further improved their therapeutic efficacy, making them versatile agents for enhancing cancer treatment outcomes. Ongoing research aims to better understand their pharmacokinetics, biodistribution, and long-term safety, paving the way for their broader application in advanced cancer therapies.https://www.mdpi.com/2079-4991/15/1/39gold nanoclusterstargeted cancer therapyradiotherapyphotodynamic therapyphotothermal therapyPDT |
| spellingShingle | Zoey A. Lockwood Michael R. Jirousek James P. Basilion Clemens Burda Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies Nanomaterials gold nanoclusters targeted cancer therapy radiotherapy photodynamic therapy photothermal therapy PDT |
| title | Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies |
| title_full | Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies |
| title_fullStr | Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies |
| title_full_unstemmed | Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies |
| title_short | Applications of Au<sub>25</sub> Nanoclusters in Photon-Based Cancer Therapies |
| title_sort | applications of au sub 25 sub nanoclusters in photon based cancer therapies |
| topic | gold nanoclusters targeted cancer therapy radiotherapy photodynamic therapy photothermal therapy PDT |
| url | https://www.mdpi.com/2079-4991/15/1/39 |
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