Progress in magnetic resonance imaging of the glymphatic system
The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of cerebral interstitial fluid (ISF) and cerebrospinal fluid (CSF). GS occurs through a normal exchange w...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2024-11-01
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| Series: | Magnetic Resonance Letters |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772516224000615 |
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| _version_ | 1846150101445115904 |
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| author | Jinhao Lyu Xinyu Wang Qi Duan Wanbing Wang Runze Li Xiaoyu Wang Xin Lou |
| author_facet | Jinhao Lyu Xinyu Wang Qi Duan Wanbing Wang Runze Li Xiaoyu Wang Xin Lou |
| author_sort | Jinhao Lyu |
| collection | DOAJ |
| description | The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of cerebral interstitial fluid (ISF) and cerebrospinal fluid (CSF). GS occurs through a normal exchange within perivascular space (PVS), facilitating the elimination of metabolic wastes generated by nerve cells from the brain. Therefore, the GS is mainly responsible for the removal of metabolic waste. Reduced GS activity has been observed to be associated with central nervous system disorders such as cerebral small vessel disease (CSVD) and neurodegenerative diseases. Its activity is expected to be an indicator for diagnosing diseases and predicting their prognosis. This review introduces the magnetic resonance imaging (MRI) technology related to the GS suitable for clinical use and the difference in the system's activity in normal and abnormal states. Through a summary of previous research, imaging methods suitable for monitoring the activity of the GS in the clinic were proposed, and their diagnostic effect on different brain disorders was analyzed. This review aims to clarify ideas for the clinical translation of basic research focusing on GS and provide future clinical research directions and perspectives. |
| format | Article |
| id | doaj-art-6654aabb4aa14039976e5abaa3314dd1 |
| institution | Kabale University |
| issn | 2772-5162 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Magnetic Resonance Letters |
| spelling | doaj-art-6654aabb4aa14039976e5abaa3314dd12024-11-29T06:25:34ZengKeAi Communications Co. Ltd.Magnetic Resonance Letters2772-51622024-11-0144200154Progress in magnetic resonance imaging of the glymphatic systemJinhao Lyu0Xinyu Wang1Qi Duan2Wanbing Wang3Runze Li4Xiaoyu Wang5Xin Lou6Department of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaDepartment of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaCorresponding author.; Department of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, ChinaThe glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of cerebral interstitial fluid (ISF) and cerebrospinal fluid (CSF). GS occurs through a normal exchange within perivascular space (PVS), facilitating the elimination of metabolic wastes generated by nerve cells from the brain. Therefore, the GS is mainly responsible for the removal of metabolic waste. Reduced GS activity has been observed to be associated with central nervous system disorders such as cerebral small vessel disease (CSVD) and neurodegenerative diseases. Its activity is expected to be an indicator for diagnosing diseases and predicting their prognosis. This review introduces the magnetic resonance imaging (MRI) technology related to the GS suitable for clinical use and the difference in the system's activity in normal and abnormal states. Through a summary of previous research, imaging methods suitable for monitoring the activity of the GS in the clinic were proposed, and their diagnostic effect on different brain disorders was analyzed. This review aims to clarify ideas for the clinical translation of basic research focusing on GS and provide future clinical research directions and perspectives.http://www.sciencedirect.com/science/article/pii/S2772516224000615Glymphatic systemNeurofluidMR imagingPhysiological statusCentral nervous system disorders |
| spellingShingle | Jinhao Lyu Xinyu Wang Qi Duan Wanbing Wang Runze Li Xiaoyu Wang Xin Lou Progress in magnetic resonance imaging of the glymphatic system Magnetic Resonance Letters Glymphatic system Neurofluid MR imaging Physiological status Central nervous system disorders |
| title | Progress in magnetic resonance imaging of the glymphatic system |
| title_full | Progress in magnetic resonance imaging of the glymphatic system |
| title_fullStr | Progress in magnetic resonance imaging of the glymphatic system |
| title_full_unstemmed | Progress in magnetic resonance imaging of the glymphatic system |
| title_short | Progress in magnetic resonance imaging of the glymphatic system |
| title_sort | progress in magnetic resonance imaging of the glymphatic system |
| topic | Glymphatic system Neurofluid MR imaging Physiological status Central nervous system disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2772516224000615 |
| work_keys_str_mv | AT jinhaolyu progressinmagneticresonanceimagingoftheglymphaticsystem AT xinyuwang progressinmagneticresonanceimagingoftheglymphaticsystem AT qiduan progressinmagneticresonanceimagingoftheglymphaticsystem AT wanbingwang progressinmagneticresonanceimagingoftheglymphaticsystem AT runzeli progressinmagneticresonanceimagingoftheglymphaticsystem AT xiaoyuwang progressinmagneticresonanceimagingoftheglymphaticsystem AT xinlou progressinmagneticresonanceimagingoftheglymphaticsystem |