High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors

High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors

Abstract Central nervous system germ cell tumors (CNS-GCT) are malignant neoplasms that arise predominantly during adolescence and young adulthood. These tumors are typically sensitive to treatment, but resulting long-term health deficits are common. Additional clinical challenges include surgical r...

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Main Authors: Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T. L. Ku, Matthew M. K. Shing, Kevin K. F. Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Huang, David Malkin, Birgit Ertl-Wagner, Peter Dirks, Eric Bouffet, Ute Bartels, Uri Tabori, Cynthia Hawkins, Anthony P. Y. Liu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Acta Neuropathologica Communications
Subjects:
Central nervous system germ cell tumors
Cell-free DNA
Circulating-tumor DNA
Liquid biopsies
Measurable residual disease
Online Access:https://doi.org/10.1186/s40478-024-01886-w
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https://doi.org/10.1186/s40478-024-01886-w

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