Unfolded protein responses in T cell immunity
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are integral to T cell biology, influencing immune responses and associated diseases. This review explores the interplay between the UPR and T cell immunity, highlighting the role of these cellular processes in T cell activati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1515715/full |
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| _version_ | 1841555679106564096 |
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| author | Wencan Zhang Xu Cao |
| author_facet | Wencan Zhang Xu Cao |
| author_sort | Wencan Zhang |
| collection | DOAJ |
| description | Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are integral to T cell biology, influencing immune responses and associated diseases. This review explores the interplay between the UPR and T cell immunity, highlighting the role of these cellular processes in T cell activation, differentiation, and function. The UPR, mediated by IRE1, PERK, and ATF6, is crucial for maintaining ER homeostasis and supporting T cell survival under stress. However, the precise mechanisms by which ER stress and the UPR regulate T cell-mediated immunity remain incompletely understood. Emerging evidence suggests that the UPR may be a potential therapeutic target for diseases characterized by T cell dysfunction, such as autoimmune disorders and cancer. Further research is needed to elucidate the complex interactions between ER stress, the UPR, and T cell immunity to develop novel therapeutic strategies for T cell-associated diseases. |
| format | Article |
| id | doaj-art-662a82f76f554edb86e9fc4315bd80a0 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-662a82f76f554edb86e9fc4315bd80a02025-01-08T05:10:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15157151515715Unfolded protein responses in T cell immunityWencan Zhang0Xu Cao1Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Frontiers Science Center for Drug Target Identification and Delivery, and the Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, ChinaEndoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are integral to T cell biology, influencing immune responses and associated diseases. This review explores the interplay between the UPR and T cell immunity, highlighting the role of these cellular processes in T cell activation, differentiation, and function. The UPR, mediated by IRE1, PERK, and ATF6, is crucial for maintaining ER homeostasis and supporting T cell survival under stress. However, the precise mechanisms by which ER stress and the UPR regulate T cell-mediated immunity remain incompletely understood. Emerging evidence suggests that the UPR may be a potential therapeutic target for diseases characterized by T cell dysfunction, such as autoimmune disorders and cancer. Further research is needed to elucidate the complex interactions between ER stress, the UPR, and T cell immunity to develop novel therapeutic strategies for T cell-associated diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1515715/fullendoplasmic reticulum stressunfolded protein responseT cell activationT cell differentiationimmune regulation |
| spellingShingle | Wencan Zhang Xu Cao Unfolded protein responses in T cell immunity Frontiers in Immunology endoplasmic reticulum stress unfolded protein response T cell activation T cell differentiation immune regulation |
| title | Unfolded protein responses in T cell immunity |
| title_full | Unfolded protein responses in T cell immunity |
| title_fullStr | Unfolded protein responses in T cell immunity |
| title_full_unstemmed | Unfolded protein responses in T cell immunity |
| title_short | Unfolded protein responses in T cell immunity |
| title_sort | unfolded protein responses in t cell immunity |
| topic | endoplasmic reticulum stress unfolded protein response T cell activation T cell differentiation immune regulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1515715/full |
| work_keys_str_mv | AT wencanzhang unfoldedproteinresponsesintcellimmunity AT xucao unfoldedproteinresponsesintcellimmunity |