Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation
Abstract Background Genetic variation and modifiable risk factors play a significant role in the pathogenesis of atrial fibrillation (AF). The influence of epigenetic modification on AF remains to be elucidated. We investigated the role of DNA methylation in the etiology of AF. Epigenetic evaluation...
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BMC
2024-12-01
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| Series: | Clinical Epigenetics |
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| Online Access: | https://doi.org/10.1186/s13148-024-01794-9 |
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| author | Mi-Ryung Han Joo Hee Jeong Yun Gi Kim Hyun-Ho Yang Chang-Ok Seo Yeji Kim Hyoung Seok Lee Jaemin Shim Young-Hoon Kim Jong-Il Choi |
| author_facet | Mi-Ryung Han Joo Hee Jeong Yun Gi Kim Hyun-Ho Yang Chang-Ok Seo Yeji Kim Hyoung Seok Lee Jaemin Shim Young-Hoon Kim Jong-Il Choi |
| author_sort | Mi-Ryung Han |
| collection | DOAJ |
| description | Abstract Background Genetic variation and modifiable risk factors play a significant role in the pathogenesis of atrial fibrillation (AF). The influence of epigenetic modification on AF remains to be elucidated. We investigated the role of DNA methylation in the etiology of AF. Epigenetic evaluation was performed in 115 AF patients who underwent radiofrequency catheter ablation in a single institution. We measured methylation at approximately 850,000 bp cytosine-phosphate-guanine (CpG) sites in the 115 samples. The degree of methylation was compared across seven classification criteria: type of AF, late recurrence, impaired left atrium (LA) function, late gadolinium enhancement, LA diameter, LA volume, and flow velocity of the LA appendage. Results The four most significantly methylated genes were DEFB104B, C3, TANC1, and TMEM9B. The DEFB104B gene (cg20223677 in the transcription start site), which encodes β-defensin 104B, was hypomethylated in three groups: AF patients with late recurrence, impaired LA function, and impaired LAA flow velocity. Enriched functional annotation of the differentially methylated datasets revealed that five out of the seven AF groups in this cohort were associated with genes involved in the cell movement of endothelial cell lines, sprouting angiogenesis by endothelial cell lines, or migration of endothelial cell lines. Conclusions Epigenetic profiling revealed that epigenetic modification might affect important characteristics of AF. Our results suggest that the pathogenesis of AF might be affected by not only genetic variation or modifiable factors but also by epigenetic modulation. |
| format | Article |
| id | doaj-art-661c0e5d1ff34571ad52981633f056b5 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-661c0e5d1ff34571ad52981633f056b52024-12-22T12:33:29ZengBMCClinical Epigenetics1868-70832024-12-0116111410.1186/s13148-024-01794-9Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillationMi-Ryung Han0Joo Hee Jeong1Yun Gi Kim2Hyun-Ho Yang3Chang-Ok Seo4Yeji Kim5Hyoung Seok Lee6Jaemin Shim7Young-Hoon Kim8Jong-Il Choi9Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National UniversityDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National UniversityDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalDivision of Cardiology, Korea University College of Medicine, Korea University Anam HospitalAbstract Background Genetic variation and modifiable risk factors play a significant role in the pathogenesis of atrial fibrillation (AF). The influence of epigenetic modification on AF remains to be elucidated. We investigated the role of DNA methylation in the etiology of AF. Epigenetic evaluation was performed in 115 AF patients who underwent radiofrequency catheter ablation in a single institution. We measured methylation at approximately 850,000 bp cytosine-phosphate-guanine (CpG) sites in the 115 samples. The degree of methylation was compared across seven classification criteria: type of AF, late recurrence, impaired left atrium (LA) function, late gadolinium enhancement, LA diameter, LA volume, and flow velocity of the LA appendage. Results The four most significantly methylated genes were DEFB104B, C3, TANC1, and TMEM9B. The DEFB104B gene (cg20223677 in the transcription start site), which encodes β-defensin 104B, was hypomethylated in three groups: AF patients with late recurrence, impaired LA function, and impaired LAA flow velocity. Enriched functional annotation of the differentially methylated datasets revealed that five out of the seven AF groups in this cohort were associated with genes involved in the cell movement of endothelial cell lines, sprouting angiogenesis by endothelial cell lines, or migration of endothelial cell lines. Conclusions Epigenetic profiling revealed that epigenetic modification might affect important characteristics of AF. Our results suggest that the pathogenesis of AF might be affected by not only genetic variation or modifiable factors but also by epigenetic modulation.https://doi.org/10.1186/s13148-024-01794-9Atrial fibrillationEpigeneticsCatheter ablationRecurrence |
| spellingShingle | Mi-Ryung Han Joo Hee Jeong Yun Gi Kim Hyun-Ho Yang Chang-Ok Seo Yeji Kim Hyoung Seok Lee Jaemin Shim Young-Hoon Kim Jong-Il Choi Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation Clinical Epigenetics Atrial fibrillation Epigenetics Catheter ablation Recurrence |
| title | Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| title_full | Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| title_fullStr | Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| title_full_unstemmed | Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| title_short | Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| title_sort | epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation |
| topic | Atrial fibrillation Epigenetics Catheter ablation Recurrence |
| url | https://doi.org/10.1186/s13148-024-01794-9 |
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