Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance
Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal ca...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2306676 |
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| _version_ | 1846125984427802624 |
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| author | Chun Ye Xiao Liu Zilun Liu Chuxuan Pan Xiaowei Zhang Zhanyi Zhao Haitao Sun |
| author_facet | Chun Ye Xiao Liu Zilun Liu Chuxuan Pan Xiaowei Zhang Zhanyi Zhao Haitao Sun |
| author_sort | Chun Ye |
| collection | DOAJ |
| description | Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies associated with Fusobacterium nucleatum, including oral, pancreatic, esophageal, breast, and gastric cancers. Our central focus is to unravel the mechanisms governing Fusobacterium nucleatum colonization, initiation, and promotion of metastasis across diverse cancer types. Additionally, we explore Fusobacterium nucleatum‘s adverse impacts on cancer therapies, particularly within the domains of immunotherapy and chemotherapy. Furthermore, this paper underscores the clinical research significance of Fusobacterium nucleatum as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. |
| format | Article |
| id | doaj-art-6609df487e414189b9ec7b51fd4cc3ab |
| institution | Kabale University |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-6609df487e414189b9ec7b51fd4cc3ab2024-12-13T06:53:25ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2306676Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistanceChun Ye0Xiao Liu1Zilun Liu2Chuxuan Pan3Xiaowei Zhang4Zhanyi Zhao5Haitao Sun6Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaClinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaFusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies associated with Fusobacterium nucleatum, including oral, pancreatic, esophageal, breast, and gastric cancers. Our central focus is to unravel the mechanisms governing Fusobacterium nucleatum colonization, initiation, and promotion of metastasis across diverse cancer types. Additionally, we explore Fusobacterium nucleatum‘s adverse impacts on cancer therapies, particularly within the domains of immunotherapy and chemotherapy. Furthermore, this paper underscores the clinical research significance of Fusobacterium nucleatum as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment.https://www.tandfonline.com/doi/10.1080/15384047.2024.2306676Fusobacterium nucleatumtumorigenesistumor metastasistumor resistancemechanism |
| spellingShingle | Chun Ye Xiao Liu Zilun Liu Chuxuan Pan Xiaowei Zhang Zhanyi Zhao Haitao Sun Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance Cancer Biology & Therapy Fusobacterium nucleatum tumorigenesis tumor metastasis tumor resistance mechanism |
| title | Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance |
| title_full | Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance |
| title_fullStr | Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance |
| title_full_unstemmed | Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance |
| title_short | Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance |
| title_sort | fusobacterium nucleatum in tumors from tumorigenesis to tumor metastasis and tumor resistance |
| topic | Fusobacterium nucleatum tumorigenesis tumor metastasis tumor resistance mechanism |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2306676 |
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