Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study
Introduction: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by deficits in social-emotional reciprocity and associated behavioral symptoms. The goal of this study was to examine perinatal risk factors for ASD and their correlates in a tertiary care hospital in Dubai, Unite...
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| Format: | Article |
| Language: | English |
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Knowledge E
2023-06-01
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| Series: | Dubai Medical Journal |
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| Online Access: | https://beta.karger.com/Article/FullText/530542 |
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| author | Hussein Adamjee Burhani Sara Hussain Jeyaseelan Lakshmanan Ammar Albanna |
| author_facet | Hussein Adamjee Burhani Sara Hussain Jeyaseelan Lakshmanan Ammar Albanna |
| author_sort | Hussein Adamjee Burhani |
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| description | Introduction: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by deficits in social-emotional reciprocity and associated behavioral symptoms. The goal of this study was to examine perinatal risk factors for ASD and their correlates in a tertiary care hospital in Dubai, United Arab Emirates (UAE). Methods: We conducted a case-control study of 87 children diagnosed with ASD using the DSM-5 criteria, who were born between 1999 and 2014, and diagnosed between 2014 and 2016, and 134 age- and gender-matched control subjects. Data were collected from hospital medical records. Associations between ASD and maternal, birth, and neonatal risk factors were examined using logistic regression analysis. Results: Maternal fever was associated with ASD (p = 0.018), with 0% in the control group and 5% in the cases. Multivariate logistic regression analysis revealed a trend for an association between high birthweight (>4,000 g) and ASD (95% CI: 0.76–59.93, p = 0.086). Conclusion: The data affirmed the established gender difference of approximately four males to one female and supported previous findings associating ASD with prematurity. Larger representative studies are further required to explore risk factors for ASD in the UAE. |
| format | Article |
| id | doaj-art-65eb0b84def14f11a895768262a8a569 |
| institution | Kabale University |
| issn | 2571-726X |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Dubai Medical Journal |
| spelling | doaj-art-65eb0b84def14f11a895768262a8a5692025-01-02T05:43:10ZengKnowledge EDubai Medical Journal2571-726X2023-06-011810.1159/000530542530542Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control StudyHussein Adamjee Burhani0Sara Hussain1Jeyaseelan Lakshmanan2Ammar Albanna3https://orcid.org/0000-0001-9791-0497Pediatric and Neonatal ICU Department, Latifa Women and Children’s Hospital, Dubai Health Authority, Dubai, United Arab EmiratesEmergency Department, Rashid Hospital, Dubai Health Authority, Dubai, United Arab EmiratesBiostatistics Department, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesMental Health Center of Excellence, Al Jalila Children’s Hospital, Dubai, United Arab EmiratesIntroduction: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by deficits in social-emotional reciprocity and associated behavioral symptoms. The goal of this study was to examine perinatal risk factors for ASD and their correlates in a tertiary care hospital in Dubai, United Arab Emirates (UAE). Methods: We conducted a case-control study of 87 children diagnosed with ASD using the DSM-5 criteria, who were born between 1999 and 2014, and diagnosed between 2014 and 2016, and 134 age- and gender-matched control subjects. Data were collected from hospital medical records. Associations between ASD and maternal, birth, and neonatal risk factors were examined using logistic regression analysis. Results: Maternal fever was associated with ASD (p = 0.018), with 0% in the control group and 5% in the cases. Multivariate logistic regression analysis revealed a trend for an association between high birthweight (>4,000 g) and ASD (95% CI: 0.76–59.93, p = 0.086). Conclusion: The data affirmed the established gender difference of approximately four males to one female and supported previous findings associating ASD with prematurity. Larger representative studies are further required to explore risk factors for ASD in the UAE.https://beta.karger.com/Article/FullText/530542psychiatryperinatal risk factorsautism spectrum disorderdemographypregnancyrisk factorscase-control studiesmiddle east |
| spellingShingle | Hussein Adamjee Burhani Sara Hussain Jeyaseelan Lakshmanan Ammar Albanna Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study Dubai Medical Journal psychiatry perinatal risk factors autism spectrum disorder demography pregnancy risk factors case-control studies middle east |
| title | Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study |
| title_full | Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study |
| title_fullStr | Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study |
| title_full_unstemmed | Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study |
| title_short | Perinatal Risk Factors in Children Diagnosed with Autism Spectrum Disorder in Dubai: A Case-Control Study |
| title_sort | perinatal risk factors in children diagnosed with autism spectrum disorder in dubai a case control study |
| topic | psychiatry perinatal risk factors autism spectrum disorder demography pregnancy risk factors case-control studies middle east |
| url | https://beta.karger.com/Article/FullText/530542 |
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