Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria
Background: This study evaluated the gender-dependent potency and side effects of Highly Active Antiretroviral Therapy regimens (i) Zidovndine/Lamuvidine/ Nevirapine (ii) Tenofovir/Emtricitabine/Effavirenz on HIV-positive/AIDs patients attending Nsukka district hospital Enugu, from January 2013 to D...
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Mashhad University of Medical Sciences
2024-09-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
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| Online Access: | https://apjmt.mums.ac.ir/article_25187_5b985b9de88e3635c33c5e88f14cd3df.pdf |
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| author | Okechukwu Asadu Chibuisi Otuu Nkoyo Nubila Elvis Shu |
| author_facet | Okechukwu Asadu Chibuisi Otuu Nkoyo Nubila Elvis Shu |
| author_sort | Okechukwu Asadu |
| collection | DOAJ |
| description | Background: This study evaluated the gender-dependent potency and side effects of Highly Active Antiretroviral Therapy regimens (i) Zidovndine/Lamuvidine/ Nevirapine (ii) Tenofovir/Emtricitabine/Effavirenz on HIV-positive/AIDs patients attending Nsukka district hospital Enugu, from January 2013 to December 2013. Method: A retrospective study of two hundred (200) patients of both sexes within the age bracket of 15 – 70 years attending Nsukka District hospital who were treated with HAART was conducted. Clinical and laboratory data were obtained through self developed validated data collection form.Results: Abdominal pains and diarrhea (3.3%) were the most reported clinical manifestations in regimen 1, followed by headache and chills (2.2%) while in regimen 2, headache, hotness and dizziness (2.4%) were the most reported clinical manifestations followed by pruritis. HAART 1 showed more adverse effects than HAART 2 on both sexes on most of the biochemical variables; glucose (34.57±95.97 - 4.89±0.3 mmol/l), cholesterol (17.33±39.87 - 3.63±0.62 mmol/l), serum glucotransaminase (SGOT) (36.78±27.76 - 32.83±17.10 iu/l), blood urea nitrogen (BUN), (18.66±13.33 - 15.14±6.01mg/dl) and amylase (126.29±186.21 - 104.43±31.38 µg/l).While both regimens showed improved immunological and hematological outcomes: CD4+; 282.03±219.57 - 380.89±241.21 cells/µl (HAART1), 312.09±242.60-404.15±253.17 cells/µl (HAART2), hemoglobin(Hb) 10.60±1.74 - 10.93±1.81 g/dl (HAART1), 10.46 ±2.00 - 11.46±1.85 g/dl (HAART2).Conclusion: The adverse effects on clinical manifestation were more noticeable in regimen 1 in the study population, with the female population being the greater affected. Comparison of the two regimens with respect to their adverse effects on clinical manifestation favors regimen 2. |
| format | Article |
| id | doaj-art-65c6c75c5cbf4273ba98f7bdea22b9a5 |
| institution | Kabale University |
| issn | 2322-2611 2322-4320 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj-art-65c6c75c5cbf4273ba98f7bdea22b9a52024-12-03T06:30:28ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202024-09-011339510310.22038/apjmt.2024.81005.146225187Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, NigeriaOkechukwu Asadu0Chibuisi Otuu1Nkoyo Nubila2Elvis Shu3Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu NigeriaDepartment of Science Laboratory Technology, University of Nigeria, Nsukka, Enugu State, NigeriaDepartment of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu NigeriaDepartment of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Enugu NigeriaBackground: This study evaluated the gender-dependent potency and side effects of Highly Active Antiretroviral Therapy regimens (i) Zidovndine/Lamuvidine/ Nevirapine (ii) Tenofovir/Emtricitabine/Effavirenz on HIV-positive/AIDs patients attending Nsukka district hospital Enugu, from January 2013 to December 2013. Method: A retrospective study of two hundred (200) patients of both sexes within the age bracket of 15 – 70 years attending Nsukka District hospital who were treated with HAART was conducted. Clinical and laboratory data were obtained through self developed validated data collection form.Results: Abdominal pains and diarrhea (3.3%) were the most reported clinical manifestations in regimen 1, followed by headache and chills (2.2%) while in regimen 2, headache, hotness and dizziness (2.4%) were the most reported clinical manifestations followed by pruritis. HAART 1 showed more adverse effects than HAART 2 on both sexes on most of the biochemical variables; glucose (34.57±95.97 - 4.89±0.3 mmol/l), cholesterol (17.33±39.87 - 3.63±0.62 mmol/l), serum glucotransaminase (SGOT) (36.78±27.76 - 32.83±17.10 iu/l), blood urea nitrogen (BUN), (18.66±13.33 - 15.14±6.01mg/dl) and amylase (126.29±186.21 - 104.43±31.38 µg/l).While both regimens showed improved immunological and hematological outcomes: CD4+; 282.03±219.57 - 380.89±241.21 cells/µl (HAART1), 312.09±242.60-404.15±253.17 cells/µl (HAART2), hemoglobin(Hb) 10.60±1.74 - 10.93±1.81 g/dl (HAART1), 10.46 ±2.00 - 11.46±1.85 g/dl (HAART2).Conclusion: The adverse effects on clinical manifestation were more noticeable in regimen 1 in the study population, with the female population being the greater affected. Comparison of the two regimens with respect to their adverse effects on clinical manifestation favors regimen 2.https://apjmt.mums.ac.ir/article_25187_5b985b9de88e3635c33c5e88f14cd3df.pdfgender-dependenthiv/aidshaarthematologybiochemical |
| spellingShingle | Okechukwu Asadu Chibuisi Otuu Nkoyo Nubila Elvis Shu Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria Asia Pacific Journal of Medical Toxicology gender-dependent hiv/aids haart hematology biochemical |
| title | Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria |
| title_full | Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria |
| title_fullStr | Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria |
| title_full_unstemmed | Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria |
| title_short | Gender-dependent Side Effects of Two Highly Active Antiretroviral Therapy Regimens on HIV/AIDS Patients Attending Nsukka District Hospital, Nsukka, Enugu State, Nigeria |
| title_sort | gender dependent side effects of two highly active antiretroviral therapy regimens on hiv aids patients attending nsukka district hospital nsukka enugu state nigeria |
| topic | gender-dependent hiv/aids haart hematology biochemical |
| url | https://apjmt.mums.ac.ir/article_25187_5b985b9de88e3635c33c5e88f14cd3df.pdf |
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