Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology
Radiation therapy is an effective cancer treatment used in over 50% of cancer patients. Preclinical research in radiobiology plays a major role in influencing the translation of radiotherapy-based treatment strategies into clinical practice. Studies have demonstrated that various components of tumor...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-09-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2015.00022 |
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| _version_ | 1841563145113436160 |
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| author | Azusa Maeda Iris Kulbatski Ralph S. DaCosta |
| author_facet | Azusa Maeda Iris Kulbatski Ralph S. DaCosta |
| author_sort | Azusa Maeda |
| collection | DOAJ |
| description | Radiation therapy is an effective cancer treatment used in over 50% of cancer patients. Preclinical research in radiobiology plays a major role in influencing the translation of radiotherapy-based treatment strategies into clinical practice. Studies have demonstrated that various components of tumors and their microenvironments, including vasculature, immune and stem cells, and stromal cells, can influence the response of solid tumors to radiation. Optically enabled imaging techniques used in experimental animal models of cancer offer a unique and powerful way to quantitatively track spatiotemporal changes in these tumor components in vivo at macro-, meso-, and microscopic resolutions following radiotherapy. In this review, we discuss the role of both well-established and emerging intravital microscopy techniques for studying tumors and their microenvironment in vivo, in response to irradiation. The development and application of new animal models, small animal microirradiation technologies, and multimodal optically enabled intravital microscopy techniques are emphasized within the framework of preclinical radiobiology research. We also comment on the potential influence that these newer imaging techniques may have on the clinical translation of new preclinical radiobiology discoveries. |
| format | Article |
| id | doaj-art-65b1872bf4614459b7d1f2e2810d2a25 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-65b1872bf4614459b7d1f2e2810d2a252025-01-03T00:10:41ZengSAGE PublishingMolecular Imaging1536-01212015-09-011410.2310/7290.2015.0002210.2310_7290.2015.00022Emerging Applications for Optically Enabled Intravital Microscopic Imaging in RadiobiologyAzusa MaedaIris KulbatskiRalph S. DaCostaRadiation therapy is an effective cancer treatment used in over 50% of cancer patients. Preclinical research in radiobiology plays a major role in influencing the translation of radiotherapy-based treatment strategies into clinical practice. Studies have demonstrated that various components of tumors and their microenvironments, including vasculature, immune and stem cells, and stromal cells, can influence the response of solid tumors to radiation. Optically enabled imaging techniques used in experimental animal models of cancer offer a unique and powerful way to quantitatively track spatiotemporal changes in these tumor components in vivo at macro-, meso-, and microscopic resolutions following radiotherapy. In this review, we discuss the role of both well-established and emerging intravital microscopy techniques for studying tumors and their microenvironment in vivo, in response to irradiation. The development and application of new animal models, small animal microirradiation technologies, and multimodal optically enabled intravital microscopy techniques are emphasized within the framework of preclinical radiobiology research. We also comment on the potential influence that these newer imaging techniques may have on the clinical translation of new preclinical radiobiology discoveries.https://doi.org/10.2310/7290.2015.00022 |
| spellingShingle | Azusa Maeda Iris Kulbatski Ralph S. DaCosta Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology Molecular Imaging |
| title | Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology |
| title_full | Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology |
| title_fullStr | Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology |
| title_full_unstemmed | Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology |
| title_short | Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology |
| title_sort | emerging applications for optically enabled intravital microscopic imaging in radiobiology |
| url | https://doi.org/10.2310/7290.2015.00022 |
| work_keys_str_mv | AT azusamaeda emergingapplicationsforopticallyenabledintravitalmicroscopicimaginginradiobiology AT iriskulbatski emergingapplicationsforopticallyenabledintravitalmicroscopicimaginginradiobiology AT ralphsdacosta emergingapplicationsforopticallyenabledintravitalmicroscopicimaginginradiobiology |