Prognosis of Multifocal Papillary Thyroid Carcinoma
This study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed wi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/809382 |
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| author | Sheng-Fong Kuo Shu-Fu Lin Tzu-Chieh Chao Chuen Hsueh Kun-Ju Lin Jen-Der Lin |
| author_facet | Sheng-Fong Kuo Shu-Fu Lin Tzu-Chieh Chao Chuen Hsueh Kun-Ju Lin Jen-Der Lin |
| author_sort | Sheng-Fong Kuo |
| collection | DOAJ |
| description | This study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed with multifocal PTC. The percentage of multifocal PTC was higher in PTMC patients (22.0%) than in non-PTMC patients (19.5%). Demographic and clinical characteristics of PTMC and multifocal PTC in PTC patients were traced. Multifocal PTC patients presented with smaller tumors at an older age, and a higher percentage underwent total or complete thyroidectomy. These patients also showed a higher incidence of postoperative disease progression than did unifocal PTC patients. Comparison of 483 patients with multifocal PTMC and non-PTMC tumors showed a higher incidence of postoperative disease progression in patients with non-PTMC; otherwise, there was no statistical difference in disease-specific and total mortality between these two groups. In conclusion, the incidence of multifocal PTMC was not lower than that of non-PTMC, and postoperative therapies were necessary for both multifocal PTMC and non-PTMC patients. |
| format | Article |
| id | doaj-art-65b0aad602b64c4aa7d1d2ccd770a8b0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-65b0aad602b64c4aa7d1d2ccd770a8b02025-08-20T03:34:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/809382809382Prognosis of Multifocal Papillary Thyroid CarcinomaSheng-Fong Kuo0Shu-Fu Lin1Tzu-Chieh Chao2Chuen Hsueh3Kun-Ju Lin4Jen-Der Lin5Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanDepartment of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanDepartment of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanDepartment of Nuclear Medicine; Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, TaiwanThis study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed with multifocal PTC. The percentage of multifocal PTC was higher in PTMC patients (22.0%) than in non-PTMC patients (19.5%). Demographic and clinical characteristics of PTMC and multifocal PTC in PTC patients were traced. Multifocal PTC patients presented with smaller tumors at an older age, and a higher percentage underwent total or complete thyroidectomy. These patients also showed a higher incidence of postoperative disease progression than did unifocal PTC patients. Comparison of 483 patients with multifocal PTMC and non-PTMC tumors showed a higher incidence of postoperative disease progression in patients with non-PTMC; otherwise, there was no statistical difference in disease-specific and total mortality between these two groups. In conclusion, the incidence of multifocal PTMC was not lower than that of non-PTMC, and postoperative therapies were necessary for both multifocal PTMC and non-PTMC patients.http://dx.doi.org/10.1155/2013/809382 |
| spellingShingle | Sheng-Fong Kuo Shu-Fu Lin Tzu-Chieh Chao Chuen Hsueh Kun-Ju Lin Jen-Der Lin Prognosis of Multifocal Papillary Thyroid Carcinoma International Journal of Endocrinology |
| title | Prognosis of Multifocal Papillary Thyroid Carcinoma |
| title_full | Prognosis of Multifocal Papillary Thyroid Carcinoma |
| title_fullStr | Prognosis of Multifocal Papillary Thyroid Carcinoma |
| title_full_unstemmed | Prognosis of Multifocal Papillary Thyroid Carcinoma |
| title_short | Prognosis of Multifocal Papillary Thyroid Carcinoma |
| title_sort | prognosis of multifocal papillary thyroid carcinoma |
| url | http://dx.doi.org/10.1155/2013/809382 |
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