EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort
Given the association of Epstein-Barr virus (EBV) with subjective perception of fatigue and demyelination in clinical conditions, the question about potential subclinical effects in the adult general population remains open. We investigate the association between individuals’ EBV immune response and...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624001741 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846145883642527744 |
|---|---|
| author | Mihály Gayer Zhi Ming Xu Flavia Hodel Martin Preisig Marie-Pierre F. Strippoli Peter Vollenweider Julien Vaucher Antoine Lutti Ferath Kherif Iris-Katharina Penner Renaud Du Pasquier Jacques Fellay Bogdan Draganski |
| author_facet | Mihály Gayer Zhi Ming Xu Flavia Hodel Martin Preisig Marie-Pierre F. Strippoli Peter Vollenweider Julien Vaucher Antoine Lutti Ferath Kherif Iris-Katharina Penner Renaud Du Pasquier Jacques Fellay Bogdan Draganski |
| author_sort | Mihály Gayer |
| collection | DOAJ |
| description | Given the association of Epstein-Barr virus (EBV) with subjective perception of fatigue and demyelination in clinical conditions, the question about potential subclinical effects in the adult general population remains open. We investigate the association between individuals’ EBV immune response and perceived fatigue in a community dwelling cohort (n = 864, age 62 ± 10 years old; 49% women) while monitoring brain tissue properties. Fatigue levels are assessed with the established fatigue severity scale, the EBNA-1 and VCA p18 immunoglobulin G (IgG) chronic response – with multiplex serology and the estimates of local brain volume, myelin content, and axonal density - using relaxometry- and multi-shell diffusion-based magnetic resonance imaging (MRI). In our analysis we adjust for the effects of demographic and cardiovascular risk factors, sleep apnea, depression, and polygenic risk score for multiple sclerosis. We demonstrate that EBNA-1 IgG levels are positively associated with perceived levels of fatigue, whilst VCA p18 IgG levels show a positive correlation with myelin content and a negative one with an estimate of axonal g-ratio in male participants. In the context of EBVs immune response, the polygenic risk for multiple sclerosis is not associated with increased fatigue levels, brain myelination or atrophy. Our findings bring empirical evidence about the potential role of EBVs chronic immune response in perceived fatigue and hint towards a protective role of myelination specific for men. They underscore the added value of advanced assessment of brain tissue microstructure in uncovering the mechanisms behind frequent fatigue complaints associated with EBV infection and multiple sclerosis. |
| format | Article |
| id | doaj-art-65a5dd2b8a6e4d21a1a46c6fa0804052 |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-65a5dd2b8a6e4d21a1a46c6fa08040522024-12-02T05:06:44ZengElsevierBrain, Behavior, & Immunity - Health2666-35462024-12-0142100896EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohortMihály Gayer0Zhi Ming Xu1Flavia Hodel2Martin Preisig3Marie-Pierre F. Strippoli4Peter Vollenweider5Julien Vaucher6Antoine Lutti7Ferath Kherif8Iris-Katharina Penner9Renaud Du Pasquier10Jacques Fellay11Bogdan Draganski12LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, SwitzerlandPrecision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandPsychiatric Epidemiology and Psychopathology Research Centre, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandPsychiatric Epidemiology and Psychopathology Research Centre, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDivision of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDivision of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Division of Internal Medicine, Department of Medicine and Specialties, Fribourg Hospital and University of Fribourg, Fribourg, SwitzerlandLREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandLREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandNeurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Corresponding author. EPFL-SV-GHI, Station 19, 1015, Lausanne, Switzerland.LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Neurology Department, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Corresponding author. University Clinic for Neurology, Inselspital, Rosenbühlgasse 25, 3010, Bern, Switzerland.Given the association of Epstein-Barr virus (EBV) with subjective perception of fatigue and demyelination in clinical conditions, the question about potential subclinical effects in the adult general population remains open. We investigate the association between individuals’ EBV immune response and perceived fatigue in a community dwelling cohort (n = 864, age 62 ± 10 years old; 49% women) while monitoring brain tissue properties. Fatigue levels are assessed with the established fatigue severity scale, the EBNA-1 and VCA p18 immunoglobulin G (IgG) chronic response – with multiplex serology and the estimates of local brain volume, myelin content, and axonal density - using relaxometry- and multi-shell diffusion-based magnetic resonance imaging (MRI). In our analysis we adjust for the effects of demographic and cardiovascular risk factors, sleep apnea, depression, and polygenic risk score for multiple sclerosis. We demonstrate that EBNA-1 IgG levels are positively associated with perceived levels of fatigue, whilst VCA p18 IgG levels show a positive correlation with myelin content and a negative one with an estimate of axonal g-ratio in male participants. In the context of EBVs immune response, the polygenic risk for multiple sclerosis is not associated with increased fatigue levels, brain myelination or atrophy. Our findings bring empirical evidence about the potential role of EBVs chronic immune response in perceived fatigue and hint towards a protective role of myelination specific for men. They underscore the added value of advanced assessment of brain tissue microstructure in uncovering the mechanisms behind frequent fatigue complaints associated with EBV infection and multiple sclerosis.http://www.sciencedirect.com/science/article/pii/S2666354624001741Epstein-barr virus (EBV)FatigueDemyelinationNeuroimagingMultiple sclerosis (MS)EBV immune response |
| spellingShingle | Mihály Gayer Zhi Ming Xu Flavia Hodel Martin Preisig Marie-Pierre F. Strippoli Peter Vollenweider Julien Vaucher Antoine Lutti Ferath Kherif Iris-Katharina Penner Renaud Du Pasquier Jacques Fellay Bogdan Draganski EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort Brain, Behavior, & Immunity - Health Epstein-barr virus (EBV) Fatigue Demyelination Neuroimaging Multiple sclerosis (MS) EBV immune response |
| title | EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort |
| title_full | EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort |
| title_fullStr | EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort |
| title_full_unstemmed | EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort |
| title_short | EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain’s myelin content to fatigue in a community-dwelling cohort |
| title_sort | ebna 1 and vca p18 immunoglobulin markers link epstein barr virus immune response and brain s myelin content to fatigue in a community dwelling cohort |
| topic | Epstein-barr virus (EBV) Fatigue Demyelination Neuroimaging Multiple sclerosis (MS) EBV immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624001741 |
| work_keys_str_mv | AT mihalygayer ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT zhimingxu ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT flaviahodel ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT martinpreisig ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT mariepierrefstrippoli ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT petervollenweider ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT julienvaucher ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT antoinelutti ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT ferathkherif ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT iriskatharinapenner ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT renauddupasquier ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT jacquesfellay ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort AT bogdandraganski ebna1andvcap18immunoglobulinmarkerslinkepsteinbarrvirusimmuneresponseandbrainsmyelincontenttofatigueinacommunitydwellingcohort |