Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests
Aim: Pitavastatin (Pita) is a member of the statin family, a well-known hypolipidemic agent, and some statin members are effective in treating pain. This study aimed to evaluate the antinociceptive effects of Pita by measuring nociception in rats with different doses and durations.Material and Metho...
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Duzce University
2024-12-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/4221243 |
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| author | Tuba Ozcan Metin Duygun Altıntaş Aykan Selma Yaman |
| author_facet | Tuba Ozcan Metin Duygun Altıntaş Aykan Selma Yaman |
| author_sort | Tuba Ozcan Metin |
| collection | DOAJ |
| description | Aim: Pitavastatin (Pita) is a member of the statin family, a well-known hypolipidemic agent, and some statin members are effective in treating pain. This study aimed to evaluate the antinociceptive effects of Pita by measuring nociception in rats with different doses and durations.Material and Methods: This study consisted of six groups including saline oral as a non-drug control, 1 mg/kg Pita single dose, 3 mg/kg Pita single dose, 1 mg/kg Pita for 14 days, 3 mg/kg Pita for 14 days, and 20 mg/kg diclofenac for 14 days. Thermal plantar and mechanical plantar tests were used to observe pain threshold changes. Correlations between Pita doses, durations, and behavioral pain responses were evaluated. The sciatic nerves were evaluated histopathologically.Results: Pita showed a significant antinociceptive effect in the dynamic plantar test at doses of 1 mg/kg for 14 days by increasing the mechanical threshold from 25.43±4.79 g to 32.28±2.27 g (p=0.041) and 3 mg/kg for 14 days by increasing the mechanical threshold from 27.41±2.36 g to 34.35±2.58 g (p=0.039). Also, Pita increased the thermal latency from 8.95±1.28 s to 11.71±1.49 s in the thermal plantar test at a single dose of 3 mg/kg (p=0.004). Although the antinociceptive effects of Pita were proven in dynamic plantar and thermal plantar tests, these findings did not reach a significant level at histopathological evaluation.Conclusion: These results suggest that Pita has an antinociceptive effect and when used in conjunction with the right dosage and timing, might be favored for the treatment of pain. |
| format | Article |
| id | doaj-art-65a0a623fbf34c978b28fc0e8db6f0b7 |
| institution | Kabale University |
| issn | 1307-671X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Duzce University |
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| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj-art-65a0a623fbf34c978b28fc0e8db6f0b72024-12-25T18:29:26ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2024-12-0126321422010.18678/dtfd.155165797Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar TestsTuba Ozcan Metin0https://orcid.org/0000-0003-0624-026XDuygun Altıntaş Aykan1https://orcid.org/0000-0001-8224-4006Selma Yaman2https://orcid.org/0000-0002-9301-9119KAHRAMANMARAS SUTCU IMAM UNIVERSITYKAHRAMANMARAS SUTCU IMAM UNIVERSITYKAHRAMANMARAS SUTCU IMAM UNIVERSITYAim: Pitavastatin (Pita) is a member of the statin family, a well-known hypolipidemic agent, and some statin members are effective in treating pain. This study aimed to evaluate the antinociceptive effects of Pita by measuring nociception in rats with different doses and durations.Material and Methods: This study consisted of six groups including saline oral as a non-drug control, 1 mg/kg Pita single dose, 3 mg/kg Pita single dose, 1 mg/kg Pita for 14 days, 3 mg/kg Pita for 14 days, and 20 mg/kg diclofenac for 14 days. Thermal plantar and mechanical plantar tests were used to observe pain threshold changes. Correlations between Pita doses, durations, and behavioral pain responses were evaluated. The sciatic nerves were evaluated histopathologically.Results: Pita showed a significant antinociceptive effect in the dynamic plantar test at doses of 1 mg/kg for 14 days by increasing the mechanical threshold from 25.43±4.79 g to 32.28±2.27 g (p=0.041) and 3 mg/kg for 14 days by increasing the mechanical threshold from 27.41±2.36 g to 34.35±2.58 g (p=0.039). Also, Pita increased the thermal latency from 8.95±1.28 s to 11.71±1.49 s in the thermal plantar test at a single dose of 3 mg/kg (p=0.004). Although the antinociceptive effects of Pita were proven in dynamic plantar and thermal plantar tests, these findings did not reach a significant level at histopathological evaluation.Conclusion: These results suggest that Pita has an antinociceptive effect and when used in conjunction with the right dosage and timing, might be favored for the treatment of pain.https://dergipark.org.tr/en/download/article-file/4221243ağrıpitavastatinantiallodinik etkiantihyperaljesik etkipitavastatinantialoodynic effectantihyperalgesic effectpain |
| spellingShingle | Tuba Ozcan Metin Duygun Altıntaş Aykan Selma Yaman Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests Düzce Tıp Fakültesi Dergisi ağrı pitavastatin antiallodinik etki antihyperaljesik etki pitavastatin antialoodynic effect antihyperalgesic effect pain |
| title | Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests |
| title_full | Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests |
| title_fullStr | Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests |
| title_full_unstemmed | Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests |
| title_short | Evaluation of the Efficacy of Pitavastatin on Pain Response in Rats with Thermal Plantar and Dynamic Plantar Tests |
| title_sort | evaluation of the efficacy of pitavastatin on pain response in rats with thermal plantar and dynamic plantar tests |
| topic | ağrı pitavastatin antiallodinik etki antihyperaljesik etki pitavastatin antialoodynic effect antihyperalgesic effect pain |
| url | https://dergipark.org.tr/en/download/article-file/4221243 |
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