Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer
Background. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/340851 |
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| author | Gaetan Des Guetz Bernard Uzzan Thierry Bouillet Patrick Nicolas Kader Chouahnia Laurent Zelek Jean-François Morere |
| author_facet | Gaetan Des Guetz Bernard Uzzan Thierry Bouillet Patrick Nicolas Kader Chouahnia Laurent Zelek Jean-François Morere |
| author_sort | Gaetan Des Guetz |
| collection | DOAJ |
| description | Background. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. No dedicated MA was found in the Cochrane Library. References were cross-checked. Pre- and postdiagnosis PA levels were assessed by MET. Usually, “high” PA was higher than 17 MET hour/week. Hazard ratios (HRs) for OS and CSS were calculated, with their 95% confidence interval. We used more conservative adjusted HRs, since variables of adjustment were similar between studies. When higher PA was associated with improved survival, HRs for detrimental events were set to <1. We used EasyMA software and fixed effect model whenever possible. Results. Seven studies (8056 participants) were included, representing 3762 men and 4256 women, 5210 colon and 1745 rectum cancers. Mean age was 67 years. HR CSS for postdiagnosis PA (higher PA versus lower) was 0.61 (0.44–0.86). The corresponding HR OS was 0.62 (0.54–0.71). HR CSS for prediagnosis PA was 0.75 (0.62–0.91). The corresponding HR OS was 0.74 (0.62–0.89). Conclusion. Higher PA predicted a better CSS. Sustained PA should be advised for CRC. OS also improved (reduced cardiovascular risk). |
| format | Article |
| id | doaj-art-65a07caa10ca42b18d6e2168ebd28779 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-65a07caa10ca42b18d6e2168ebd287792025-02-03T05:47:46ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/340851340851Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal CancerGaetan Des Guetz0Bernard Uzzan1Thierry Bouillet2Patrick Nicolas3Kader Chouahnia4Laurent Zelek5Jean-François Morere6Department of Medical Oncology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Pharmacology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Radiotherapy, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Pharmacology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Medical Oncology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Medical Oncology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceDepartment of Medical Oncology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, FranceBackground. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. No dedicated MA was found in the Cochrane Library. References were cross-checked. Pre- and postdiagnosis PA levels were assessed by MET. Usually, “high” PA was higher than 17 MET hour/week. Hazard ratios (HRs) for OS and CSS were calculated, with their 95% confidence interval. We used more conservative adjusted HRs, since variables of adjustment were similar between studies. When higher PA was associated with improved survival, HRs for detrimental events were set to <1. We used EasyMA software and fixed effect model whenever possible. Results. Seven studies (8056 participants) were included, representing 3762 men and 4256 women, 5210 colon and 1745 rectum cancers. Mean age was 67 years. HR CSS for postdiagnosis PA (higher PA versus lower) was 0.61 (0.44–0.86). The corresponding HR OS was 0.62 (0.54–0.71). HR CSS for prediagnosis PA was 0.75 (0.62–0.91). The corresponding HR OS was 0.74 (0.62–0.89). Conclusion. Higher PA predicted a better CSS. Sustained PA should be advised for CRC. OS also improved (reduced cardiovascular risk).http://dx.doi.org/10.1155/2013/340851 |
| spellingShingle | Gaetan Des Guetz Bernard Uzzan Thierry Bouillet Patrick Nicolas Kader Chouahnia Laurent Zelek Jean-François Morere Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer Gastroenterology Research and Practice |
| title | Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer |
| title_full | Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer |
| title_fullStr | Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer |
| title_full_unstemmed | Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer |
| title_short | Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer |
| title_sort | impact of physical activity on cancer specific and overall survival of patients with colorectal cancer |
| url | http://dx.doi.org/10.1155/2013/340851 |
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