Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy
Asn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of different compounds for imaging and therapy. When con...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012120934957 |
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| author | Liqin Zhu MD Zhikai Ding MD Xingliang Li PhD Hongyuan Wei PhD Yue Chen MD |
| author_facet | Liqin Zhu MD Zhikai Ding MD Xingliang Li PhD Hongyuan Wei PhD Yue Chen MD |
| author_sort | Liqin Zhu MD |
| collection | DOAJ |
| description | Asn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of different compounds for imaging and therapy. When conjugated with NGR, complexes recognize the CD13 receptor expressed on the tumor vasculature, which improves the specificity to tumor and avoids systematic toxic reactions. Both preclinical and clinical studies performed with these products suggest that NGR-mediated vascular targeting is an effective strategy for delivering bioactive amounts of cytokines to tumor endothelial cells. For molecular imaging, radiolabeled peptides have been the most successful approach and have been translated into clinic. This review describes current data on radiolabeled tumor vasculature-homing NGR peptides for imaging and therapy. |
| format | Article |
| id | doaj-art-65973550f6654e94aa1628f60783fec7 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-65973550f6654e94aa1628f60783fec72025-01-02T21:31:26ZengSAGE PublishingMolecular Imaging1536-01212020-08-011910.1177/1536012120934957Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and TherapyLiqin Zhu MD0Zhikai Ding MD1Xingliang Li PhD2Hongyuan Wei PhD3Yue Chen MD4 Department of Nuclear Medicine, , Luzhou, Sichuan, People’s Republic of China Department of Nuclear Medicine, , Luzhou, Sichuan, People’s Republic of China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of ChinaAsn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of different compounds for imaging and therapy. When conjugated with NGR, complexes recognize the CD13 receptor expressed on the tumor vasculature, which improves the specificity to tumor and avoids systematic toxic reactions. Both preclinical and clinical studies performed with these products suggest that NGR-mediated vascular targeting is an effective strategy for delivering bioactive amounts of cytokines to tumor endothelial cells. For molecular imaging, radiolabeled peptides have been the most successful approach and have been translated into clinic. This review describes current data on radiolabeled tumor vasculature-homing NGR peptides for imaging and therapy.https://doi.org/10.1177/1536012120934957 |
| spellingShingle | Liqin Zhu MD Zhikai Ding MD Xingliang Li PhD Hongyuan Wei PhD Yue Chen MD Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy Molecular Imaging |
| title | Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy |
| title_full | Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy |
| title_fullStr | Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy |
| title_full_unstemmed | Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy |
| title_short | Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy |
| title_sort | research progress of radiolabeled asn gly arg ngr peptides for imaging and therapy |
| url | https://doi.org/10.1177/1536012120934957 |
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