Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair
Abstract Abdominal aortic aneurysms (AAAs) involve localized dilation of the abdominal aorta, with the reversal of this condition being significantly limited by the inherently poor and abnormal regenerative repair of the aortic elastic matrix. Mesenchymal stem cell exosomes (MSCEs) are promising reg...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405085 |
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| author | Lulu Wang Yao Zhang Chun Mao Xiaoqiang Li |
| author_facet | Lulu Wang Yao Zhang Chun Mao Xiaoqiang Li |
| author_sort | Lulu Wang |
| collection | DOAJ |
| description | Abstract Abdominal aortic aneurysms (AAAs) involve localized dilation of the abdominal aorta, with the reversal of this condition being significantly limited by the inherently poor and abnormal regenerative repair of the aortic elastic matrix. Mesenchymal stem cell exosomes (MSCEs) are promising regenerative tools; however, achieving precise targeting of AAA with MSCEs is challenging owing to the high blood flow in the arterial system. In this study, an engineered exosomal nanomotor is developed for magnetic and chemical propulsion. The results demonstrate that this nanomotor effectively enhances the delivery of MSCEs to the AAA through magnetic field navigation and catalase‐induced chemotaxis. The nanomotor significantly enhances the elastic matrix repair, reduces oxidative stress, and activates the PI3K/Akt pathway, leading to aneurysm shrinkage and reversal. In addition, the nanomotor possesses magnetic resonance imaging capabilities. The use of this nanomotor offers a novel, targeted drug delivery system in a rat model of AAA and holds promise as a potential therapeutic option for this condition. |
| format | Article |
| id | doaj-art-65897ca619a74b3f807ef33dcb1f97b0 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-65897ca619a74b3f807ef33dcb1f97b02024-12-11T16:00:49ZengWileyAdvanced Science2198-38442024-12-011146n/an/a10.1002/advs.202405085Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative RepairLulu Wang0Yao Zhang1Chun Mao2Xiaoqiang Li3Department of Vascular Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu 210008 ChinaNational and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing Jiangsu 210023 ChinaDepartment of Vascular Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu 210008 ChinaDepartment of Vascular Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu 210008 ChinaAbstract Abdominal aortic aneurysms (AAAs) involve localized dilation of the abdominal aorta, with the reversal of this condition being significantly limited by the inherently poor and abnormal regenerative repair of the aortic elastic matrix. Mesenchymal stem cell exosomes (MSCEs) are promising regenerative tools; however, achieving precise targeting of AAA with MSCEs is challenging owing to the high blood flow in the arterial system. In this study, an engineered exosomal nanomotor is developed for magnetic and chemical propulsion. The results demonstrate that this nanomotor effectively enhances the delivery of MSCEs to the AAA through magnetic field navigation and catalase‐induced chemotaxis. The nanomotor significantly enhances the elastic matrix repair, reduces oxidative stress, and activates the PI3K/Akt pathway, leading to aneurysm shrinkage and reversal. In addition, the nanomotor possesses magnetic resonance imaging capabilities. The use of this nanomotor offers a novel, targeted drug delivery system in a rat model of AAA and holds promise as a potential therapeutic option for this condition.https://doi.org/10.1002/advs.202405085abdominal aortic aneurysmselastic matrix regenerative repairexosomal deliverynanomotorsreversal |
| spellingShingle | Lulu Wang Yao Zhang Chun Mao Xiaoqiang Li Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair Advanced Science abdominal aortic aneurysms elastic matrix regenerative repair exosomal delivery nanomotors reversal |
| title | Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair |
| title_full | Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair |
| title_fullStr | Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair |
| title_full_unstemmed | Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair |
| title_short | Enhancing Exosomal Delivery to Abdominal Aortic Aneurysms using Magnetically Responsive Chemotactic Nanomotors for Elastic Matrix Regenerative Repair |
| title_sort | enhancing exosomal delivery to abdominal aortic aneurysms using magnetically responsive chemotactic nanomotors for elastic matrix regenerative repair |
| topic | abdominal aortic aneurysms elastic matrix regenerative repair exosomal delivery nanomotors reversal |
| url | https://doi.org/10.1002/advs.202405085 |
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