Integrated proteogenomic characterization of ampullary adenocarcinoma
Abstract Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation. Pro...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-024-00742-4 |
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| author | Qiao Zhang Xiaomeng Xu Dongxian Jiang Yunzhi Wang Haixing Wang Jiajun Zhu Shaoshuai Tang Ronghua Wang Shuang Zhao Kai Li Jinwen Feng Hang Xiang Zhenmei Yao Ning Xu Rundong Fang Wenjia Guo Yu Liu Yingyong Hou Chen Ding |
| author_facet | Qiao Zhang Xiaomeng Xu Dongxian Jiang Yunzhi Wang Haixing Wang Jiajun Zhu Shaoshuai Tang Ronghua Wang Shuang Zhao Kai Li Jinwen Feng Hang Xiang Zhenmei Yao Ning Xu Rundong Fang Wenjia Guo Yu Liu Yingyong Hou Chen Ding |
| author_sort | Qiao Zhang |
| collection | DOAJ |
| description | Abstract Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation. Proteomic analysis has revealed three distinct clusters (C-FAM, C-AD, C-CC), among which the most aggressive cluster, C-AD, is associated with the poorest prognosis and is characterized by focal adhesion. Immune clustering identifies three immune clusters and reveals that immune cluster M1 (macrophage infiltration cluster) and M3 (DC cell infiltration cluster), which exhibit a higher immune score compared to cluster M2 (CD4+ T-cell infiltration cluster), are associated with a poor prognosis due to the potential secretion of IL-6 by tumor cells and its consequential influence. This study provides a comprehensive proteogenomic analysis for seeking for better understanding and potential treatment of AMPAC. |
| format | Article |
| id | doaj-art-653e28d7e83242d7bba46b164d05d94f |
| institution | Kabale University |
| issn | 2056-5968 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Discovery |
| spelling | doaj-art-653e28d7e83242d7bba46b164d05d94f2025-01-12T12:07:57ZengNature Publishing GroupCell Discovery2056-59682025-01-0111112510.1038/s41421-024-00742-4Integrated proteogenomic characterization of ampullary adenocarcinomaQiao Zhang0Xiaomeng Xu1Dongxian Jiang2Yunzhi Wang3Haixing Wang4Jiajun Zhu5Shaoshuai Tang6Ronghua Wang7Shuang Zhao8Kai Li9Jinwen Feng10Hang Xiang11Zhenmei Yao12Ning Xu13Rundong Fang14Wenjia Guo15Yu Liu16Yingyong Hou17Chen Ding18Center for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityDepartment of Pathology, Zhongshan Hospital Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityPediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Jiao Tong UniversityPediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Jiao Tong UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityDepartments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Xinjiang Key Laboratory of Translational Biomedical EngineeringPediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Jiao Tong UniversityDepartment of Pathology, Zhongshan Hospital Fudan UniversityCenter for Cell and Gene Therapy, Clinical Research Center for Cell-based Immunotherapy, Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan UniversityAbstract Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation. Proteomic analysis has revealed three distinct clusters (C-FAM, C-AD, C-CC), among which the most aggressive cluster, C-AD, is associated with the poorest prognosis and is characterized by focal adhesion. Immune clustering identifies three immune clusters and reveals that immune cluster M1 (macrophage infiltration cluster) and M3 (DC cell infiltration cluster), which exhibit a higher immune score compared to cluster M2 (CD4+ T-cell infiltration cluster), are associated with a poor prognosis due to the potential secretion of IL-6 by tumor cells and its consequential influence. This study provides a comprehensive proteogenomic analysis for seeking for better understanding and potential treatment of AMPAC.https://doi.org/10.1038/s41421-024-00742-4 |
| spellingShingle | Qiao Zhang Xiaomeng Xu Dongxian Jiang Yunzhi Wang Haixing Wang Jiajun Zhu Shaoshuai Tang Ronghua Wang Shuang Zhao Kai Li Jinwen Feng Hang Xiang Zhenmei Yao Ning Xu Rundong Fang Wenjia Guo Yu Liu Yingyong Hou Chen Ding Integrated proteogenomic characterization of ampullary adenocarcinoma Cell Discovery |
| title | Integrated proteogenomic characterization of ampullary adenocarcinoma |
| title_full | Integrated proteogenomic characterization of ampullary adenocarcinoma |
| title_fullStr | Integrated proteogenomic characterization of ampullary adenocarcinoma |
| title_full_unstemmed | Integrated proteogenomic characterization of ampullary adenocarcinoma |
| title_short | Integrated proteogenomic characterization of ampullary adenocarcinoma |
| title_sort | integrated proteogenomic characterization of ampullary adenocarcinoma |
| url | https://doi.org/10.1038/s41421-024-00742-4 |
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