Advances in Understanding the Relationship between Gut Microbiota， Probiotics and Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent hyperglycemia and insulin resistance (IR). Emerging evidence indicates that gut microbiota dysbiosis is closely linked to the onset of T2DM and the progression of IR. This review provides a comprehensive analysis of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of International Journal of Geriatrics
2024-11-01
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| Series: | Guoji laonian yixue zazhi |
| Subjects: | |
| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2024.06.001&lang=en |
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| Summary: | Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent hyperglycemia and insulin resistance (IR). Emerging evidence indicates that gut microbiota dysbiosis is closely linked to the onset of T2DM and the progression of IR. This review provides a comprehensive analysis of the intricate interactions between gut microbiota and the metabolic, inflammatory, and immune dysregulation observed in T2DM. It specifically emphasizes the mechanisms through which microbial metabolites modulate insulin signaling pathways in the context of T2DM. Additionally, the review explores the potential of probiotics as a therapeutic intervention, focusing on their ability to modulate gut microbiota and its metabolites. This review offers a theoretical framework and relevant literature to support the regulation and treatment of T2DM and its complications via gut microbiota modulation. |
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| ISSN: | 1674-7593 |