Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study
Background/Aims Nonalcoholic fatty liver disease (NAFLD) is a common disease with severe inflammatory processes associated with numerous gastrointestinal diseases, such as inflammatory bowel disease (IBD). Therefore, we investigated the relationship between NAFLD and IBD and the possible risk factor...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2025-01-01
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| Series: | Intestinal Research |
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| Online Access: | http://irjournal.org/upload/pdf/ir-2023-00078.pdf |
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| author | Ying-Hsiang Wang Chi-Hsiang Chung Tien-Yu Huang Chao-Feng Chang Chi-Wei Yang Wu-Chien Chien Yi-Chiao Cheng |
| author_facet | Ying-Hsiang Wang Chi-Hsiang Chung Tien-Yu Huang Chao-Feng Chang Chi-Wei Yang Wu-Chien Chien Yi-Chiao Cheng |
| author_sort | Ying-Hsiang Wang |
| collection | DOAJ |
| description | Background/Aims Nonalcoholic fatty liver disease (NAFLD) is a common disease with severe inflammatory processes associated with numerous gastrointestinal diseases, such as inflammatory bowel disease (IBD). Therefore, we investigated the relationship between NAFLD and IBD and the possible risk factors associated with the diagnosis of IBD. Methods This longitudinal nationwide cohort study investigated the risk of IBD in patients with NAFLD alone. General characteristics, comorbidities, and incidence of IBD were also compared. Results Patients diagnosed with NAFLD had a significant risk of developing IBD compared to control individuals, who were associated with a 2.245-fold risk of the diagnosis of IBD and a 2.260- and 2.231-fold of increased diagnosis of ulcerative colitis and Crohn’s disease, respectively (P< 0.001). The cumulative risk of IBD increased annually during the follow-up of patients with NAFLD (P< 0.001). Conclusions Our results emphasize that NAFLD significantly impacts its incidence in patients with NAFLD. If patients with NAFLD present with risk factors, such as diabetes mellitus and dyslipidemia, these conditions should be properly treated with regular follow-ups. Furthermore, we believe that these causes may be associated with the second peak of IBD. |
| format | Article |
| id | doaj-art-64ec0de131cf45eba9132974c0aacb1d |
| institution | Kabale University |
| issn | 1598-9100 2288-1956 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj-art-64ec0de131cf45eba9132974c0aacb1d2025-08-20T03:53:46ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562025-01-01231768410.5217/ir.2023.000781049Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort studyYing-Hsiang Wang0Chi-Hsiang Chung1Tien-Yu Huang2Chao-Feng Chang3Chi-Wei Yang4Wu-Chien Chien5Yi-Chiao Cheng6 Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan School of Public Health, National Defense Medical Center, Taipei, Taiwan Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan School of Public Health, National Defense Medical Center, Taipei, Taiwan Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanBackground/Aims Nonalcoholic fatty liver disease (NAFLD) is a common disease with severe inflammatory processes associated with numerous gastrointestinal diseases, such as inflammatory bowel disease (IBD). Therefore, we investigated the relationship between NAFLD and IBD and the possible risk factors associated with the diagnosis of IBD. Methods This longitudinal nationwide cohort study investigated the risk of IBD in patients with NAFLD alone. General characteristics, comorbidities, and incidence of IBD were also compared. Results Patients diagnosed with NAFLD had a significant risk of developing IBD compared to control individuals, who were associated with a 2.245-fold risk of the diagnosis of IBD and a 2.260- and 2.231-fold of increased diagnosis of ulcerative colitis and Crohn’s disease, respectively (P< 0.001). The cumulative risk of IBD increased annually during the follow-up of patients with NAFLD (P< 0.001). Conclusions Our results emphasize that NAFLD significantly impacts its incidence in patients with NAFLD. If patients with NAFLD present with risk factors, such as diabetes mellitus and dyslipidemia, these conditions should be properly treated with regular follow-ups. Furthermore, we believe that these causes may be associated with the second peak of IBD.http://irjournal.org/upload/pdf/ir-2023-00078.pdfnon-alcoholic fatty liver diseaseinflammatory bowel diseaseulcerative colitiscrohn disease |
| spellingShingle | Ying-Hsiang Wang Chi-Hsiang Chung Tien-Yu Huang Chao-Feng Chang Chi-Wei Yang Wu-Chien Chien Yi-Chiao Cheng Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study Intestinal Research non-alcoholic fatty liver disease inflammatory bowel disease ulcerative colitis crohn disease |
| title | Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study |
| title_full | Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study |
| title_fullStr | Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study |
| title_full_unstemmed | Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study |
| title_short | Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study |
| title_sort | association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease a nationwide population based cohort study |
| topic | non-alcoholic fatty liver disease inflammatory bowel disease ulcerative colitis crohn disease |
| url | http://irjournal.org/upload/pdf/ir-2023-00078.pdf |
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