New insights into constitutive neutrophil death
Abstract Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous com...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02287-1 |
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| _version_ | 1841544974057865216 |
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| author | Tong Chen Qian Ren Fengxia Ma |
| author_facet | Tong Chen Qian Ren Fengxia Ma |
| author_sort | Tong Chen |
| collection | DOAJ |
| description | Abstract Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of diverse death. Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview of current research on the mechanism and modulation of CND. More noteworthy, we also summarize the after-death events of neutrophils. The fate of neutrophils can be changed under pathological conditions, so the involvement of CND in diseases and CND-related therapeutic strategies are also addressed. |
| format | Article |
| id | doaj-art-64e536125a2946738836c09318dc7863 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-64e536125a2946738836c09318dc78632025-01-12T12:08:15ZengNature Publishing GroupCell Death Discovery2058-77162025-01-0111111110.1038/s41420-025-02287-1New insights into constitutive neutrophil deathTong Chen0Qian Ren1Fengxia Ma2State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical CollegeAbstract Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of diverse death. Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview of current research on the mechanism and modulation of CND. More noteworthy, we also summarize the after-death events of neutrophils. The fate of neutrophils can be changed under pathological conditions, so the involvement of CND in diseases and CND-related therapeutic strategies are also addressed.https://doi.org/10.1038/s41420-025-02287-1 |
| spellingShingle | Tong Chen Qian Ren Fengxia Ma New insights into constitutive neutrophil death Cell Death Discovery |
| title | New insights into constitutive neutrophil death |
| title_full | New insights into constitutive neutrophil death |
| title_fullStr | New insights into constitutive neutrophil death |
| title_full_unstemmed | New insights into constitutive neutrophil death |
| title_short | New insights into constitutive neutrophil death |
| title_sort | new insights into constitutive neutrophil death |
| url | https://doi.org/10.1038/s41420-025-02287-1 |
| work_keys_str_mv | AT tongchen newinsightsintoconstitutiveneutrophildeath AT qianren newinsightsintoconstitutiveneutrophildeath AT fengxiama newinsightsintoconstitutiveneutrophildeath |