Imidazole-based phenanthroline derivatives induce DNA damage-mediated apoptosis to suppress hepatocellular carcinoma

Imidazole-based phenanthroline derivatives induce DNA damage-mediated apoptosis to suppress hepatocellular carcinoma

Objective: This study focused on designing and subsequently screening novel phenanthroimidazole derivatives with activity as potential inhibitors of hepatocellular carcinoma. Methods: We synthesized a series of phenanthroimidazole derivatives and their molecular structures were characterized by ESI-...

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Bibliographic Details
Main Authors: Jie LIN, Shuyuan ZHOU, Hairong XIAN, Weiming CHEN, Yifan ZHANG, Weiwei ZHANG, Zhihong GUAN, Wenjie MEI
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-06-01
Series:Journal of Holistic Integrative Pharmacy
Subjects:
Phenanthroimidazole derivatives
Hepatocellular carcinoma
DNA damage
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2707368823000572
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