Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension
Background Oral microbes mediate the production of nitric oxide (NO) through the denitrification pathway. This study aimed to investigate the association between oral microbial nitrate metabolism and prognosis in acute ischemic stroke (AIS) patients.Methods This prospective, observational, single-ce...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2024.2382620 |
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| author | Yueran Ren Jingru Liang Weike Hu Jiahui Xie Yifeng Zheng Wei Song Jiajia Zhu Hongwei Zhou Qiheng Wu Yan He Jia Yin |
| author_facet | Yueran Ren Jingru Liang Weike Hu Jiahui Xie Yifeng Zheng Wei Song Jiajia Zhu Hongwei Zhou Qiheng Wu Yan He Jia Yin |
| author_sort | Yueran Ren |
| collection | DOAJ |
| description | Background Oral microbes mediate the production of nitric oxide (NO) through the denitrification pathway. This study aimed to investigate the association between oral microbial nitrate metabolism and prognosis in acute ischemic stroke (AIS) patients.Methods This prospective, observational, single-center cohort study included 124 AIS patients admitted within 24 hours of symptom onset, with 24-hour ambulatory blood pressure data. Oral swabs were collected within 24 hours. Hypertensive AIS patients were stratified by the coefficient of variation (CV) of 24-hour systolic blood pressure. Microbial composition was analyzed using LEfSe and PICRUSt2 for bacterial and functional pathway identification.Results Significant differences in oral microbiota composition were observed between hypertensive AIS patients with varying CVs. Lower CV groups showed enrichment of nitrate-reducing bacteria and “Denitrification, nitrate => nitrogen” pathways. The TAX score of oral nitrate-reducing bacteria, derived from LASSO modeling, independently correlated with 90-day modified Rankin Scale scores, serving as an independent risk factor for poor prognosis. Mediation analyses suggested indirect that the TAX score not only directly influences outcomes but also indirectly affects them by modulating 24-hour systolic blood pressure CV.Conclusions AIS patients with comorbid hypertension and higher systolic blood pressure CV exhibited reduced oral nitrate-reducing bacteria, potentially worsening outcomes. |
| format | Article |
| id | doaj-art-64d9e7a3cbbb4161b80ea1301d628f11 |
| institution | Kabale University |
| issn | 2000-2297 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-64d9e7a3cbbb4161b80ea1301d628f112024-11-26T06:52:11ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972024-12-0116110.1080/20002297.2024.2382620Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertensionYueran Ren0Jingru Liang1Weike Hu2Jiahui Xie3Yifeng Zheng4Wei Song5Jiajia Zhu6Hongwei Zhou7Qiheng Wu8Yan He9Jia Yin10Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaBackground Oral microbes mediate the production of nitric oxide (NO) through the denitrification pathway. This study aimed to investigate the association between oral microbial nitrate metabolism and prognosis in acute ischemic stroke (AIS) patients.Methods This prospective, observational, single-center cohort study included 124 AIS patients admitted within 24 hours of symptom onset, with 24-hour ambulatory blood pressure data. Oral swabs were collected within 24 hours. Hypertensive AIS patients were stratified by the coefficient of variation (CV) of 24-hour systolic blood pressure. Microbial composition was analyzed using LEfSe and PICRUSt2 for bacterial and functional pathway identification.Results Significant differences in oral microbiota composition were observed between hypertensive AIS patients with varying CVs. Lower CV groups showed enrichment of nitrate-reducing bacteria and “Denitrification, nitrate => nitrogen” pathways. The TAX score of oral nitrate-reducing bacteria, derived from LASSO modeling, independently correlated with 90-day modified Rankin Scale scores, serving as an independent risk factor for poor prognosis. Mediation analyses suggested indirect that the TAX score not only directly influences outcomes but also indirectly affects them by modulating 24-hour systolic blood pressure CV.Conclusions AIS patients with comorbid hypertension and higher systolic blood pressure CV exhibited reduced oral nitrate-reducing bacteria, potentially worsening outcomes.https://www.tandfonline.com/doi/10.1080/20002297.2024.2382620Oral microbiotanitric oxideacute ischemic strokeprognosishypertensionblood pressure |
| spellingShingle | Yueran Ren Jingru Liang Weike Hu Jiahui Xie Yifeng Zheng Wei Song Jiajia Zhu Hongwei Zhou Qiheng Wu Yan He Jia Yin Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension Journal of Oral Microbiology Oral microbiota nitric oxide acute ischemic stroke prognosis hypertension blood pressure |
| title | Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| title_full | Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| title_fullStr | Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| title_full_unstemmed | Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| title_short | Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| title_sort | association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension |
| topic | Oral microbiota nitric oxide acute ischemic stroke prognosis hypertension blood pressure |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2024.2382620 |
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