Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma

Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma

Patients with osteosarcoma (OS), a debilitating pediatric bone malignancy, have limited treatment options to combat aggressive disease. OS thrives on insulin growth factor (IGF)-mediated signaling that can facilitate cell proliferation. Previous efforts to target IGF-1R signaling were mostly unsucce...

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Bibliographic Details
Main Authors: Safiya Khurshid, Akila S. Venkataramany, Matias Montes, John F. Kipp, Ryan D. Roberts, Nicolas Wein, Frank Rigo, Pin-Yi Wang, Timothy P. Cripe, Dawn S. Chandler
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
alternative splicing
insulin receptor
splice-switching oligonucleotides
U7 snRNA
osteosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924001504
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