The DNA Replication Stress Hypothesis of Alzheimer’s Disease

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

A well-recognized theory of Alzheimer’s disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. Chromosome reduplication wi...

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Bibliographic Details
Main Authors: Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2011/625690
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