Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease
Renal ischemia-reperfusion (IR) induces tissue hypoxia, resulting in disrupted energy metabolism and heightened oxidative stress. These factors contribute to tubular cell damage, which is a leading cause of acute kidney injury (AKI) and can progress to chronic kidney disease (CKD). The excessive gen...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1506909/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540117036007424 |
|---|---|
| author | Xian Liu Qin Yu Hai-Bo Mao Jing-Bo Hu Wei-Hua Liu |
| author_facet | Xian Liu Qin Yu Hai-Bo Mao Jing-Bo Hu Wei-Hua Liu |
| author_sort | Xian Liu |
| collection | DOAJ |
| description | Renal ischemia-reperfusion (IR) induces tissue hypoxia, resulting in disrupted energy metabolism and heightened oxidative stress. These factors contribute to tubular cell damage, which is a leading cause of acute kidney injury (AKI) and can progress to chronic kidney disease (CKD). The excessive generation of reactive oxygen species (ROS) plays a crucial role in the pathogenesis of AKI. This study presents the synthesis of curcumin ultra-small coordination polymer (Ru/Cur) nanodots and their application in scavenging ROS in renal tissues. By adding ruthenium ions to a methanol solution containing the natural product curcumin, ultra-small Ru/Cur nanodots were successfully synthesized. To enhance the dispersibility of these nanoparticles in water, polyvinylpyrrolidone (PVP) was used as a growth aid, resulting in highly stable nanodots with sizes smaller than 10 nm. The results indicated that Ru/Cur nanodots effectively eliminated various ROS and demonstrated significant therapeutic effects and biocompatibility in IR-AKI mice, reducing markers of kidney function damage, alleviating renal oxidative stress, and decreasing inflammatory cell infiltration. Ru/Cur nanodots inhibited renal fibrosis by suppressing epithelial-mesenchymal transition and the secretion of transforming growth factor-β1 in the model of IR-AKI to chronic kidney disease (CKD). In summary, our findings confirm that Ru/Cur nanodots mitigate the pathological conditions associated with both AKI and its progression to CKD by reducing IR-induced tubular cell injury. |
| format | Article |
| id | doaj-art-64a6edf8482248c0b09fa82736a7aaf1 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-64a6edf8482248c0b09fa82736a7aaf12025-01-14T06:10:45ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15069091506909Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney diseaseXian Liu0Qin Yu1Hai-Bo Mao2Jing-Bo Hu3Wei-Hua Liu4Department of Urology, Beilun People’s Hospital, Ningbo, Zhejiang, ChinaDepartment of Urology, Beilun People’s Hospital, Ningbo, Zhejiang, ChinaFaculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, ChinaFaculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, ChinaDepartment of Urology, Beilun People’s Hospital, Ningbo, Zhejiang, ChinaRenal ischemia-reperfusion (IR) induces tissue hypoxia, resulting in disrupted energy metabolism and heightened oxidative stress. These factors contribute to tubular cell damage, which is a leading cause of acute kidney injury (AKI) and can progress to chronic kidney disease (CKD). The excessive generation of reactive oxygen species (ROS) plays a crucial role in the pathogenesis of AKI. This study presents the synthesis of curcumin ultra-small coordination polymer (Ru/Cur) nanodots and their application in scavenging ROS in renal tissues. By adding ruthenium ions to a methanol solution containing the natural product curcumin, ultra-small Ru/Cur nanodots were successfully synthesized. To enhance the dispersibility of these nanoparticles in water, polyvinylpyrrolidone (PVP) was used as a growth aid, resulting in highly stable nanodots with sizes smaller than 10 nm. The results indicated that Ru/Cur nanodots effectively eliminated various ROS and demonstrated significant therapeutic effects and biocompatibility in IR-AKI mice, reducing markers of kidney function damage, alleviating renal oxidative stress, and decreasing inflammatory cell infiltration. Ru/Cur nanodots inhibited renal fibrosis by suppressing epithelial-mesenchymal transition and the secretion of transforming growth factor-β1 in the model of IR-AKI to chronic kidney disease (CKD). In summary, our findings confirm that Ru/Cur nanodots mitigate the pathological conditions associated with both AKI and its progression to CKD by reducing IR-induced tubular cell injury.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1506909/fullacute kidney injurychronic kidney diseaseischemia-reperfusioncurcuminruthenium |
| spellingShingle | Xian Liu Qin Yu Hai-Bo Mao Jing-Bo Hu Wei-Hua Liu Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease Frontiers in Bioengineering and Biotechnology acute kidney injury chronic kidney disease ischemia-reperfusion curcumin ruthenium |
| title | Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease |
| title_full | Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease |
| title_fullStr | Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease |
| title_full_unstemmed | Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease |
| title_short | Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease |
| title_sort | ultra small curcumin ruthenium coordination polymer nanodots prevent renal ischemia reperfusion injury and the progression to chronic kidney disease |
| topic | acute kidney injury chronic kidney disease ischemia-reperfusion curcumin ruthenium |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1506909/full |
| work_keys_str_mv | AT xianliu ultrasmallcurcuminrutheniumcoordinationpolymernanodotspreventrenalischemiareperfusioninjuryandtheprogressiontochronickidneydisease AT qinyu ultrasmallcurcuminrutheniumcoordinationpolymernanodotspreventrenalischemiareperfusioninjuryandtheprogressiontochronickidneydisease AT haibomao ultrasmallcurcuminrutheniumcoordinationpolymernanodotspreventrenalischemiareperfusioninjuryandtheprogressiontochronickidneydisease AT jingbohu ultrasmallcurcuminrutheniumcoordinationpolymernanodotspreventrenalischemiareperfusioninjuryandtheprogressiontochronickidneydisease AT weihualiu ultrasmallcurcuminrutheniumcoordinationpolymernanodotspreventrenalischemiareperfusioninjuryandtheprogressiontochronickidneydisease |