Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability

Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability

Objectives: The brain mobilizes glucose in emergency situations such as hypoglycemia as well as during day-to-day physiology such as fasting. While most hypothalamic neuronal populations that contribute to glucose mobilization also contribute to other aspects of metabolism, neurons in the ventromedi...

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Main Authors: Jiaao Su, Abdullah Hashsham, Nandan Kodur, Carla Burton, Amanda Mancuso, Anjan Singer, Jennifer Wloszek, Abigail J. Tomlinson, Warren T. Yacawych, Jonathan N. Flak, Kenneth T. Lewis, Lily R. Oles, Hiroyuki Mori, Nadejda Bozadjieva-Kramer, Adina F. Turcu, Ormond A. MacDougald, Martin G. Myers, Alison H. Affinati
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Glucose metabolism
Hypothalamus
Lipolysis
Sympathetic nervous system
Hepatic glucose production
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001231
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