Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia
<b>Aim:</b> The aim of this study is to evaluate the effects of meloxicam on serum vitamin and cytokine levels during lipopolysaccharide-induced endotoxemia. Serum biochemical concentrations were also evaluated.<p> <b>Materials and Methods:</b> Fifty male adult Sprague...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=464 |
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| author | Akile Ozlem Yurt |
| author_facet | Akile Ozlem Yurt |
| author_sort | Akile Ozlem Yurt |
| collection | DOAJ |
| description | <b>Aim:</b> The aim of this study is to evaluate the effects of
meloxicam on serum vitamin and cytokine levels during
lipopolysaccharide-induced endotoxemia. Serum biochemical
concentrations were also evaluated.<p>
<b>Materials and Methods:</b> Fifty male adult Sprague Dawley
rats were used in this research. Five rats were reserved to
obtain 0 time data then the rest were divided into 3 equal
groups. First group received lipopolysaccharide (4 mg, intraperitoneal),
second group received meloxicam (50 mg/
kg, intraperitoneal) and third group received lipopolysaccharide
(4 mg, intraperitoneal) plus meloxicam (50 mg/kg,
intraperitoneal). Blood samples were collected at 2, 4 and
8 hours after administrations. Serum retinol, β-carotene,
vitamin C, interleukin-1α, interleukin-1β, interleukin-2 and
routine biochemical values were measured.<p>
<b>Results:</b> After lipopolysaccharide administration, decreased
β-carotene level (p<0.05) was inhibited by meloxicam
while increased interleukin-1α level (p<0.05) could
not. Lipopolysaccharide caused increase in damage indicator
levels of heart, liver, kidney besides cholesterol and
triglyceride (p<0.05) while meloxicam administration was
inhibited increase in creatine kinase-MB and cholesterol
levels but caused more increase in urea and triglyceride
levels.<p>
<b>Conclusion:</b> Meloxicam may be useful in inhibiting vitamin
loses and heart damage. In addition, non-steroidal anti-inflammatory
drug and vitamin supplementation may be useful
during acute phase of endotoxemia. |
| format | Article |
| id | doaj-art-6499fb6450a94186bb4789e774c0cd8f |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-6499fb6450a94186bb4789e774c0cd8f2025-01-03T01:36:14ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532814753464Effect of meloxicam on serum vitamin and cytokine levels during endotoxemiaAkile Ozlem Yurt<b>Aim:</b> The aim of this study is to evaluate the effects of meloxicam on serum vitamin and cytokine levels during lipopolysaccharide-induced endotoxemia. Serum biochemical concentrations were also evaluated.<p> <b>Materials and Methods:</b> Fifty male adult Sprague Dawley rats were used in this research. Five rats were reserved to obtain 0 time data then the rest were divided into 3 equal groups. First group received lipopolysaccharide (4 mg, intraperitoneal), second group received meloxicam (50 mg/ kg, intraperitoneal) and third group received lipopolysaccharide (4 mg, intraperitoneal) plus meloxicam (50 mg/kg, intraperitoneal). Blood samples were collected at 2, 4 and 8 hours after administrations. Serum retinol, β-carotene, vitamin C, interleukin-1α, interleukin-1β, interleukin-2 and routine biochemical values were measured.<p> <b>Results:</b> After lipopolysaccharide administration, decreased β-carotene level (p<0.05) was inhibited by meloxicam while increased interleukin-1α level (p<0.05) could not. Lipopolysaccharide caused increase in damage indicator levels of heart, liver, kidney besides cholesterol and triglyceride (p<0.05) while meloxicam administration was inhibited increase in creatine kinase-MB and cholesterol levels but caused more increase in urea and triglyceride levels.<p> <b>Conclusion:</b> Meloxicam may be useful in inhibiting vitamin loses and heart damage. In addition, non-steroidal anti-inflammatory drug and vitamin supplementation may be useful during acute phase of endotoxemia.http://eurasianjvetsci.org/pdf.php3?id=464meloxicamendotoxemiavitamincytokin |
| spellingShingle | Akile Ozlem Yurt Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia Eurasian Journal of Veterinary Sciences meloxicam endotoxemia vitamin cytokin |
| title | Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| title_full | Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| title_fullStr | Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| title_full_unstemmed | Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| title_short | Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| title_sort | effect of meloxicam on serum vitamin and cytokine levels during endotoxemia |
| topic | meloxicam endotoxemia vitamin cytokin |
| url | http://eurasianjvetsci.org/pdf.php3?id=464 |
| work_keys_str_mv | AT akileozlemyurt effectofmeloxicamonserumvitaminandcytokinelevelsduringendotoxemia |