WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy

WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy

Background Immune checkpoint inhibitors (ICIs) are therapeutically effective for hepatocellular carcinoma (HCC) but are individually selective. This study examined the role of specific common fragile sites (CFSs) related gene in HCC immunotherapy.Methods We analyzed HCC tissues using next-generation...

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Main Authors: Min Xu, Mien-Chie Hung, Qiang Zhou, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Ning Ren, Chenhao Zhou, Jialei Weng, Shaoqing Liu, Minghao Xu, Shiguang Yang, Zhiqiu Hu
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e010422.full
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